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ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE
http://hdl.handle.net/10295/3063
http://hdl.handle.net/10295/3063cd2eeda5-f7ae-417a-8846-4dffc02fda29
| 名前 / ファイル | ライセンス | アクション |
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senoo5.pdf (800.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2016-04-20 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 作成者 |
SENOO, Haruki
× SENOO, Haruki
× WAKE, Kenjiro
× MOMOI, Takashi
× YOSHIKURA, Hiroshi
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| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | We have previously demonstrated that HL-60 cells pretreated with 1α,25-dihydroxyvitamin D3 at the stage of commitment were induced to differentiate into macrophage- like cells by dimethyl sulfoxide (OMSO) at the stage of promotion (15). To investigate the effect of OMSO on the differentiation of HL-60 cells induced by 1α,25-dihydroxyvitamin D3, three variant clones (ORHL-1, ORHL-2 and ORHL-3 cells) resistant to 1α,25-dihydroxyvitamin D3 were iso1α,ted from a OMSO-resistant cell clone (ORHL) ofHL-60 cells. These variant clones were insusceptible to 1α,25- dihydroxyvitamin D3 or OMSO, when based on the criteria of cell growth, expression of antigens for human monocyte specific (OKMS) or human granulocyte specific (80H5) monoclona1α,ntibodies, NBT-reducing activity, phagocytosis, nonspecific esterase activity, and cathepsin Band 1α,ctivities. The variant clones, ORHL-1 and ORHL-3, which were insusceptible to 1α,25-dihydroxyvitamin D3 or OMSO alone, were induced to differentiate into macrophage-like cells on simultaneous treatment with 1α,25-dihydroxyvitamin D3 and OMSO. Furthermore, ORHL-1 but not ORHL-3 differentiated into macrophage-like cells on I-day treatment with 1α,,25-dihydroxyvitamin D3 followed by 3-day treatment with OMSO. The other variant, ORHL-2, did not differentiate with any combination of 1α,25-dihydroxyvitamin D3 and OMSO. These results suggest that OMSO promotes the differentiation of HL-60 cells initiated by 1α,,25-dihydroxyvitamin D3 into macrophages at various stages of differentiation. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 書誌情報 |
en : Biomedical Research 巻 7, 号 5, p. 311-319, 発行日 1986 |
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| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 03886107 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00110128 | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Biomedical Research Foundation | |||||||||||||
| 言語 | en | |||||||||||||
| 関連情報 | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | http://doi.org/10.2220/biomedres.7.311 | |||||||||||||
