{"created":"2023-07-25T10:23:06.311851+00:00","id":2703,"links":{},"metadata":{"_buckets":{"deposit":"78352484-58cc-43af-a015-2b5af2ae1a8e"},"_deposit":{"created_by":15,"id":"2703","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2703"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002703","sets":["611:939:940"]},"author_link":["9948","9949","9950","9951"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"319","bibliographicPageStart":"311","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Biomedical Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We have previously demonstrated that HL-60 cells pretreated with 1α,25-dihydroxyvitamin D3 at the stage of commitment were induced to differentiate into macrophage- like cells by dimethyl sulfoxide (OMSO) at the stage of promotion (15). To investigate the effect of OMSO on the differentiation of HL-60 cells induced by 1α,25-dihydroxyvitamin D3, three variant clones (ORHL-1, ORHL-2 and ORHL-3 cells) resistant to 1α,25-dihydroxyvitamin D3 were iso1α,ted from a OMSO-resistant cell clone (ORHL) ofHL-60 cells. These variant clones were insusceptible to 1α,25- dihydroxyvitamin D3 or OMSO, when based on the criteria of cell growth, expression of antigens for human monocyte specific (OKMS) or human granulocyte specific (80H5) monoclona1α,ntibodies, NBT-reducing activity, phagocytosis, nonspecific esterase activity, and cathepsin Band 1α,ctivities. The variant clones, ORHL-1 and ORHL-3, which were insusceptible to 1α,25-dihydroxyvitamin D3 or OMSO alone, were induced to differentiate into macrophage-like cells on simultaneous treatment with 1α,25-dihydroxyvitamin D3 and OMSO. Furthermore, ORHL-1 but not ORHL-3 differentiated into macrophage-like cells on I-day treatment with 1α,,25-dihydroxyvitamin D3 followed by 3-day treatment with OMSO. The other variant, ORHL-2, did not differentiate with any combination of 1α,25-dihydroxyvitamin D3 and OMSO. These results suggest that OMSO promotes the differentiation of HL-60 cells initiated by 1α,,25-dihydroxyvitamin D3 into macrophages at various stages of differentiation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Biomedical Research Foundation","subitem_publisher_language":"en"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.2220/biomedres.7.311","subitem_relation_type_select":"DOI"}}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"03886107","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00110128","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SENOO, Haruki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WAKE, Kenjiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MOMOI, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YOSHIKURA, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9951","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"senoo5.pdf","filesize":[{"value":"800.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"senoo5.pdf","url":"https://air.repo.nii.ac.jp/record/2703/files/senoo5.pdf"},"version_id":"e3e60279-3bb1-4011-bce2-2cf4ed464ea1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-04-20"},"publish_date":"2016-04-20","publish_status":"0","recid":"2703","relation_version_is_last":true,"title":["ISOLATION AND CHARACTERIZATION OF CLONES OF A HUMAN LEUKEMIA CELL LINE (HL-60 CELLS) RESISTANT TO 1α,25-DIHYDROXYVITAMIN D3 AND DIMETHYL SULFOXIDE"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-25T09:07:13.081692+00:00"}