| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-19 |
| タイトル |
|
|
タイトル |
Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nitric oxide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
low molecular weight heparin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cardiovascular remodeling |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
L-NAME |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
HASEGAWA, Hitoshi
SAITO, Takashi
FUJIWARA, Yoshimasa
KUROKAWA, Fukiko
[ほか]
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To evaluate the effect of low molecular weight heparin (LMWH) on cardiovascular remodeling induced by long term inhibition of nitric oxide synthase with N-nitro-L-arginine methyl ester (L-NAME), 40 male Sprague-Dawley rats were randomly divided into four groups: the control group (n=10) that received 0.9% salt solution; the L-NAME group (n=10) that received 30 mg/kg/day of L-NAME, the LMWH3000 group (n=10) that received 30 mg/kg/day of L-NAME and 4 mg/kg/day of LMWH (molecular weight (M.W.) of 3000) and the LMWH6000 group (n= 10) that received 30 mg/kg/day of L-NAME and 4 mg/kg/day of LMWH (M.W. 6000). All agents, including saline, were administered intraperitoneally by implantation of osmotic mini pumps. Systolic blood pressure was measured by the tail-cuff method on treatment days 1,7, 14, and 28, and histological examination of harvested cardiac tissue and coronary arteries was performed on day 28. Systolic blood pressure was greater in the L-NAME, LMWH3000 and LMWH6000 groups when compared with the control group. There were no significant differences in activated coagulation time (ACT) when comparing the four groups. Medial smooth muscle cell proliferation and hypertrophy and increases in perivascular and myocardial fibrosis were observed in the L-NAME group compared with the control group. Further, these changes were inhibited by the coadministration of LMWH3000 or LWMH6000. This study demonstrates that LMWH prevents cardiovascular remodeling induced by L-NAME in rat hearts independent of its anticoagulant activity. Low molecular weight heparin prevents cardiovascular remodeling |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 31,
号 3-4,
p. 221-230,
発行日 2004-12-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akigaku31-34g.pdf (782.1 kB)
