{"created":"2023-07-25T10:22:15.370723+00:00","id":1562,"links":{},"metadata":{"_buckets":{"deposit":"94e969b4-5601-4cec-a3c8-b59e664ac716"},"_deposit":{"created_by":3,"id":"1562","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1562"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00001562","sets":["611:862:863:866"]},"author_link":["5661","5662","5664","5663","5665"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"230","bibliographicPageStart":"221","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"To evaluate the effect of low molecular weight heparin (LMWH) on\ncardiovascular remodeling induced by long term inhibition of nitric oxide synthase with\nN-nitro-L-arginine methyl ester (L-NAME), 40 male Sprague-Dawley rats were randomly\ndivided into four groups: the control group (n=10) that received 0.9% salt\nsolution; the L-NAME group (n=10) that received 30 mg/kg/day of L-NAME, the\nLMWH3000 group (n=10) that received 30 mg/kg/day of L-NAME and 4 mg/kg/day\nof LMWH (molecular weight (M.W.) of 3000) and the LMWH6000 group (n= 10)\nthat received 30 mg/kg/day of L-NAME and 4 mg/kg/day of LMWH (M.W. 6000).\nAll agents, including saline, were administered intraperitoneally by implantation of\nosmotic mini pumps. Systolic blood pressure was measured by the tail-cuff method on\ntreatment days 1,7, 14, and 28, and histological examination of harvested cardiac tissue\nand coronary arteries was performed on day 28. Systolic blood pressure was greater in\nthe L-NAME, LMWH3000 and LMWH6000 groups when compared with the control\ngroup. There were no significant differences in activated coagulation time (ACT)\nwhen comparing the four groups. Medial smooth muscle cell proliferation and hypertrophy\nand increases in perivascular and myocardial fibrosis were observed in the L-NAME\ngroup compared with the control group. Further, these changes were inhibited by the\ncoadministration of LMWH3000 or LWMH6000. This study demonstrates that LMWH\nprevents cardiovascular remodeling induced by L-NAME in rat hearts independent of its\nanticoagulant activity. Low molecular weight heparin prevents cardiovascular remodeling","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HASEGAWA, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAITO, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"FUJIWARA, Yoshimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KUROKAWA, Fukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"[ほか]"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akigaku31-34g.pdf","filesize":[{"value":"782.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akigaku31-34g.pdf","url":"https://air.repo.nii.ac.jp/record/1562/files/akigaku31-34g.pdf"},"version_id":"44fc3e3c-7c39-4c61-a3e9-14ffdd87fe9b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"nitric oxide","subitem_subject_scheme":"Other"},{"subitem_subject":"low molecular weight heparin","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiovascular remodeling","subitem_subject_scheme":"Other"},{"subitem_subject":"L-NAME","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts"}]},"item_type_id":"10001","owner":"3","path":["866"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-19"},"publish_date":"2009-01-19","publish_status":"0","recid":"1562","relation_version_is_last":true,"title":["Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T11:49:42.430408+00:00"}