| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-18 |
| タイトル |
|
|
タイトル |
尿路上皮癌患者の尿中剥離細胞における17番染色体数およびHER-2遺伝子異常の臨床的意義 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Clonical Significance of Chromosome 17 and HER-2 Numerical Alterations in Urine-Exfoliated Cells in Patients with Urothelial Carcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
FISH |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
HER-2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cytology |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
井上, 高光
佐藤, 一成
飯沼, 昌宏
土谷, 順彦
羽淵, 友則
加藤, 哲郎
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study was conducted to elucidate the clinical significance of the alterations of HER-2 gene (HER-2) and chromosome 17 centromere in urine-exfoliated cells by fluorescence in situ hybridization (FISH) in 103 patients with urothelial transitional cell carcinoma. The additional increase of HER-2 (AI-HER2), gain of chromosome 17 (G-17), and AI-HER2 with G-17 (AI-HER2+G-17) in the urine-exfoliated cells were examined by FISH using DNA probes for HER-2 and chromosome 17 centromere. AI-HER2, AI-HER2+G-17, and G-17 were found in 13 (12.6%), 10 (9.7%), and 36 (35.0%) patients, respectively. The positive rate of the FISH (AIHER2, AI-HER2+G-17, or G-17) was higher than that of cytology in total cases (57.3% vs. 45.6%, P<0.001), in low-stage (pTa-I) tumors (44.3% vs. 27.9%, P= 0.003), and in cases without CIS (42.0% vs. 31.9%, p<O.OOI). AI-HER2 was significantly more frequent in tumors with two or more recurrences (25.9% vs. 7.9%, P=0.037). AI-HER2+ G-17 was more frequent in cases with primary CIS than without CIS (26.7% vs. 3.0%, p =0.008). Numerical alterations of HER-2 and the chromosome 17 centromere in the urine-exfoliated cells detected by FISH may reflect the malignant potential of urothelial carcinoma and could be used as markers for the recurrence and the presence of primary CIS. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
秋田医学
巻 31,
号 1,
p. 63-69,
発行日 2004-05-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
akigaku31-1f.pdf (643.8 kB)
