{"created":"2023-07-25T10:22:14.539317+00:00","id":1543,"links":{},"metadata":{"_buckets":{"deposit":"3480ae5c-21e3-4284-a86b-fbecc5024cfb"},"_deposit":{"created_by":3,"id":"1543","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1543"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00001543","sets":["611:862:863:864"]},"author_link":["5583","5588","5584","5587","5578","5580","5577","5586","5581","5579","5585","5582"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clonical Significance of Chromosome 17 and HER-2 Numerical Alterations in Urine-Exfoliated Cells in Patients with Urothelial Carcinoma"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"63","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"This study was conducted to elucidate the clinical significance of the\nalterations of HER-2 gene (HER-2) and chromosome 17 centromere in urine-exfoliated\ncells by fluorescence in situ hybridization (FISH) in 103 patients with urothelial\ntransitional cell carcinoma. The additional increase of HER-2 (AI-HER2), gain of\nchromosome 17 (G-17), and AI-HER2 with G-17 (AI-HER2+G-17) in the urine-exfoliated\ncells were examined by FISH using DNA probes for HER-2 and chromosome\n17 centromere. AI-HER2, AI-HER2+G-17, and G-17 were found in 13 (12.6%), 10\n(9.7%), and 36 (35.0%) patients, respectively. The positive rate of the FISH (AIHER2,\nAI-HER2+G-17, or G-17) was higher than that of cytology in total cases (57.3%\nvs. 45.6%, P<0.001), in low-stage (pTa-I) tumors (44.3% vs. 27.9%, P= 0.003), and in\ncases without CIS (42.0% vs. 31.9%, p<O.OOI). AI-HER2 was significantly more frequent\nin tumors with two or more recurrences (25.9% vs. 7.9%, P=0.037). AI-HER2+\nG-17 was more frequent in cases with primary CIS than without CIS (26.7% vs. 3.0%,\np =0.008). Numerical alterations of HER-2 and the chromosome 17 centromere in the\nurine-exfoliated cells detected by FISH may reflect the malignant potential of urothelial\ncarcinoma and could be used as markers for the recurrence and the presence of primary\nCIS.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井上, 高光"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 一成"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飯沼, 昌宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土谷, 順彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"羽淵, 友則"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加藤, 哲郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"INOUE, Takamitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATO, Kazunari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IINUMA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUCHIYA, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HABUCHI, Tomonori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KATO, Tetsuro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akigaku31-1f.pdf","filesize":[{"value":"643.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akigaku31-1f.pdf","url":"https://air.repo.nii.ac.jp/record/1543/files/akigaku31-1f.pdf"},"version_id":"615be373-9c3b-4dc2-aa4e-960a890cda1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"FISH","subitem_subject_scheme":"Other"},{"subitem_subject":"HER-2","subitem_subject_scheme":"Other"},{"subitem_subject":"cytology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"尿路上皮癌患者の尿中剥離細胞における17番染色体数およびHER-2遺伝子異常の臨床的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"尿路上皮癌患者の尿中剥離細胞における17番染色体数およびHER-2遺伝子異常の臨床的意義"}]},"item_type_id":"10001","owner":"3","path":["864"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-18"},"publish_date":"2009-01-18","publish_status":"0","recid":"1543","relation_version_is_last":true,"title":["尿路上皮癌患者の尿中剥離細胞における17番染色体数およびHER-2遺伝子異常の臨床的意義"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-25T11:50:08.763418+00:00"}