ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 20 医学系研究科・医学部
  2. 20A 学術誌論文
  3. 20A1 雑誌掲載論文

Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts

http://hdl.handle.net/10295/00006268
http://hdl.handle.net/10295/00006268
842522d3-40ee-4da0-b3c5-e1c481bfcacf
名前 / ファイル ライセンス アクション
iA_2022_94.pdf iA_2022_94.pdf (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-02-25
タイトル
タイトル Cdc42 regulates cell polarization and contractile actomyosin rings during terminal differentiation of human erythroblasts
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 Ubukawa, Kumi

× Ubukawa, Kumi

en Ubukawa, Kumi

Search repository
Goto, Tatsufumi

× Goto, Tatsufumi

en Goto, Tatsufumi

Search repository
Asanuma, Ken

× Asanuma, Ken

en Asanuma, Ken

Search repository
Sasaki, Yumi

× Sasaki, Yumi

en Sasaki, Yumi

Search repository
Guo, Yong-Mei

× Guo, Yong-Mei

en Guo, Yong-Mei

Search repository
Kobayashi, Isuzu

× Kobayashi, Isuzu

en Kobayashi, Isuzu

Search repository
Sawada, Kenichi

× Sawada, Kenichi

en Sawada, Kenichi

Search repository
Wakui, Hideki

× Wakui, Hideki

en Wakui, Hideki

Search repository
Takahashi, Naoto

× Takahashi, Naoto

en Takahashi, Naoto

Search repository
内容記述
内容記述タイプ Abstract
内容記述 The molecular mechanisms involved in the terminal differentiation of erythroblasts have been elucidated by comparing enucleation and cell division. Although various similarities and differences between erythroblast enucleation and cytokinesis have been reported, the mechanisms that control enucleation remain unclear. We previously reported that dynein and microtubule-organizing centers mediated the polarization of nuclei in human erythroblasts. Moreover, the accumulation of F-actin was noted during the enucleation of erythroblasts. Therefore, during enucleation, upstream effectors in the signal transduction pathway regulating dynein or actin, such as cell division control protein 42 homolog (Cdc42), may be crucial. We herein investigated the effects of the Cdc42 inhibitor, CASIN, on cytokinesis and enucleation in colony-forming units-erythroid (CFU-Es) and mature erythroblasts (day 10). CASIN blocked the proliferation of CFU-Es and their enucleation in a dose-dependent manner. Dynein adopted an island-like distribution in the cytoplasm of non-treated CFU-Es, but was concentrated near the nucleus as a dot and co-localized with gamma -tubulin in CASIN-treated cells. CASIN blocked the accumulation of F-actin in CFU-Es and day 10 cells. These results demonstrated that Cdc42 plays an important role in cytokinesis, nuclear polarization and nuclear extrusion through a relationship with dynein and actin filament organization during the terminal differentiation of erythroblasts.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : SCIENTIFIC REPORTS

巻 10, 発行日 2020
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2045-2322
出版者
出版者 Nature Research
言語 en
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-020-68799-1
権利情報
権利情報 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
戻る
0
views
See details
Views

Versions

Ver.1 2023-07-25 10:39:11.911994
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3