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Comparison of quality of human serum albumin preparations in two pharmaceutical products
http://hdl.handle.net/10295/00006187
http://hdl.handle.net/10295/00006187ce59cd59-526f-4383-a5d3-97f369aeb0aa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
iA_2022_52.pdf (177.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-02-19 | |||||
| タイトル | ||||||
| タイトル | Comparison of quality of human serum albumin preparations in two pharmaceutical products | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Endotoxin | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | mercaptoalbumin | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | non-mercaptoalbumin | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | b-D-glucan | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 作成者 |
Nakae, Hajime
× Nakae, Hajime× Tomida, Kouki× Kikuya, Yoshihiro× Okuyama, Manabu× Igarashi, Toshiko |
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| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim Human serum albumin (HSA) is known for its multiple functions, such as maintenance of colloid osmotic pressure, transport of endogenous and exogenous substances, and antioxidation. The aim of this study was to measure the redox state and concentrations of β-d-glucan and endotoxin to compare the quality of 5% HSA preparations from two different manufacturers. Methods The quality of 5% HSA preparations in two different pharmaceutical products (groups A and B) was compared in terms of the percentage of reduced and oxidized albumin and the contaminant level of β-d-glucan and endotoxin. Results The percentage of human mercaptoalbumin in group A was significantly higher than that in group B (P < 0.01), whereas that of human non-mercaptoalbumin-2 in group A was significantly lower (P < 0.01). The concentration of β-d-glucan in group A was significantly lower than in group B (P < 0.01). Conclusions The present findings indicate the need for quality control of HSA preparations in applications involving the use of large volumes. |
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| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 書誌情報 |
en : ACUTE MEDICINE & SURGERY 巻 4, 号 3, p. 251-254, 発行日 2017 |
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| 収録物識別子 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2052-8817 | |||||
| 出版者 | ||||||
| 出版者 | John Wiley and Sons Inc | |||||
| 関連情報 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/ams2.259 | |||||
| 権利情報 | ||||||
| 権利情報 | © 2017 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
