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  1. 20 医学系研究科・医学部
  2. 20A 学術誌論文
  3. 20A1 雑誌掲載論文

Macrophage numbers in the marginal area of sarcomas predict clinical prognosis

http://hdl.handle.net/10295/00006156
http://hdl.handle.net/10295/00006156
ef5d73b0-115e-499c-85ae-a8ce365078d5
名前 / ファイル ライセンス アクション
iA_2022_27.pdf iA_2022_27.pdf (1.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-02-18
タイトル
タイトル Macrophage numbers in the marginal area of sarcomas predict clinical prognosis
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 Umakoshi, Michinobu

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en Umakoshi, Michinobu

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Nakamura, Akiko

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Tsuchie, Hiroyuki

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en Tsuchie, Hiroyuki

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Li, Zhuo

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Kudo‑Asabe, Yukitsugu

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en Kudo‑Asabe, Yukitsugu

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Miyabe, Ken

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Ito, Yukinobu

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Yoshida, Makoto

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Nagasawa, Hiroyuki

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Okada, Kyoji

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Nanjo, Hiroshi

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Maeda, Daichi

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Miyakoshi, Naohisa

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Tanaka, Masamitsu

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Goto, Akiteru

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内容記述
内容記述タイプ Abstract
内容記述 Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-positive macrophages in the intratumoral and marginal areas was counted. We then performed statistical analysis to examine links between macrophage numbers, clinical factors, and outcomes. A high number of macrophages positive for all markers in both areas was associated with worse disease-free survival (DFS). Next, we divided cases according to the FNCLCC classification (Grade 1 and Grades 2/3). In the Grade 1 group, there was no significant association between macrophage number and DFS. However, in the Grade 2/3 group, high numbers of CD163- and CD204-positive macrophages in the marginal area were associated with poor DFS. By contrast, there was no significant difference between the groups with respect to high or low numbers of CD68-, CD163-, or CD204-positive macrophages in the intratumoral area. Multivariate analysis identified the number of CD163- and CD204-positive macrophages in the marginal area as an independent prognostic factor. Macrophage numbers in the marginal area of soft-tissue sarcoma may better reflect clinical behavior.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : Scientific Reports

巻 13, 号 1, 発行日 2023
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 20452322
出版者
出版者 Nature Research
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-023-28024-1
権利情報
権利情報 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2023
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