| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-01-30 |
| タイトル |
|
|
タイトル |
Tissue flow regulates planar cell polarity independently of the Frizzled core pathway |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
planar cell polarity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PCP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Drosophila |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
extracellular matrix |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
apical extracellular matrix |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ECM |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
aECM |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
dumpy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ayukawa, Tomonori
Akiyama, Masakazu
Hozumi, Yasukazu
Ishimoto, Kenta
Sasaki, Junko
Senoo, Haruki
Sasaki, Takehiko
Yamazaki, Masakazu
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Planar cell polarity (PCP) regulates the orientation of external structures. A core group of proteins that includes Frizzled forms the heart of the PCP regulatory system. Other PCP mechanisms that are independent of the core group likely exist, but their underlying mechanisms are elusive. Here, we show that tissue flow is a mechanism governing core group-independent PCP on the Drosophila notum. Loss of core group function only slightly affects bristle orientation in the adult central notum. This near-normal PCP results from tissue flow-mediated rescue of random bristle orientation during the pupal stage. Manipulation studies suggest that tissue flow can orient bristles in the opposite direction to the flow. This process is independent of the core group and implies that the apical extracellular matrix functions like a “comb” to align bristles. Our results reveal the significance of cooperation between tissue dynamics and extracellular substances in PCP establishment. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Cell Reports
巻 40,
号 12,
発行日 2022
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
22111247 |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.celrep.2022.111388 |
| 権利情報 |
|
|
権利情報 |
© 2022 The Author(s).
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
iA_2022_24.pdf (6.3 MB)
