{"created":"2023-07-25T10:25:28.579139+00:00","id":5838,"links":{},"metadata":{"_buckets":{"deposit":"ff48281f-c376-4edc-b4cd-617e42a43c52"},"_deposit":{"created_by":15,"id":"5838","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5838"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005838","sets":["611:939:940"]},"author_link":["16499","16500","16501","16502","16503","16504","16505","16506"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Cell Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Planar cell polarity (PCP) regulates the orientation of external structures. A core group of proteins that includes Frizzled forms the heart of the PCP regulatory system. Other PCP mechanisms that are independent of the core group likely exist, but their underlying mechanisms are elusive. Here, we show that tissue flow is a mechanism governing core group-independent PCP on the Drosophila notum. Loss of core group function only slightly affects bristle orientation in the adult central notum. This near-normal PCP results from tissue flow-mediated rescue of random bristle orientation during the pupal stage. Manipulation studies suggest that tissue flow can orient bristles in the opposite direction to the flow. This process is independent of the core group and implies that the apical extracellular matrix functions like a “comb” to align bristles. Our results reveal the significance of cooperation between tissue dynamics and extracellular substances in PCP establishment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.celrep.2022.111388","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2022 The Author(s). \nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"22111247","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ayukawa, Tomonori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akiyama, Masakazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hozumi, Yasukazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishimoto, Kenta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Junko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Senoo, Haruki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Takehiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Masakazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16506","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-30"}],"displaytype":"detail","filename":"iA_2022_24.pdf","filesize":[{"value":"6.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_24.pdf","url":"https://air.repo.nii.ac.jp/record/5838/files/iA_2022_24.pdf"},"version_id":"fa16f0c3-a315-4593-9c48-135098bf2ed3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"planar cell polarity","subitem_subject_scheme":"Other"},{"subitem_subject":"PCP","subitem_subject_scheme":"Other"},{"subitem_subject":"Drosophila","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix","subitem_subject_scheme":"Other"},{"subitem_subject":"apical extracellular matrix","subitem_subject_scheme":"Other"},{"subitem_subject":"ECM","subitem_subject_scheme":"Other"},{"subitem_subject":"aECM","subitem_subject_scheme":"Other"},{"subitem_subject":"dumpy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tissue flow regulates planar cell polarity independently of the Frizzled core pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tissue flow regulates planar cell polarity independently of the Frizzled core pathway","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-01-30"},"publish_date":"2023-01-30","publish_status":"0","recid":"5838","relation_version_is_last":true,"title":["Tissue flow regulates planar cell polarity independently of the Frizzled core pathway"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-24T14:03:10.373720+00:00"}