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Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis
http://hdl.handle.net/10295/00006143
http://hdl.handle.net/10295/000061433c6f2a7c-e245-4af1-a2d5-031d32b21d17
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
iA_2022_17.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-01-30 | |||||
| タイトル | ||||||
| タイトル | Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Carotid sinus baroreceptor | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Carotid artery stenosis | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Carotid artery stenting | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Carotid endarterectomy | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardiac sympathetic nerve activity | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | HFpEF | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | 123I-MIBG scintigraphy | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Echocardiography | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 作成者 |
Kato, Tsukasa
× Kato, Tsukasa× Sato, Wakana× Sato, Teruki× Shimizu, Hiroaki× Watanabe, Hiroyuki |
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| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The carotid sinus baroreceptor reflex controls the neural regulation of blood pressure. Baroreceptor disorders due to carotid sinus atherosclerosis have detrimental cardiovascular effects. This study investigated the medium-term effects of carotid artery revascularization (CAR) on sympathetic and cardiac function and systemic blood pressure variability in patients with carotid artery stenosis. Methods: This study included 21 consecutive patients (median age 70 years, 18 men) with carotid artery stenosis scheduled for CAR. 123I metaiodobenzylguanidine (MIBG) scintigraphy, echocardiography, brain natriuretic peptide levels, 24-h Holter electrocardiography (ECG), and ambulatory blood pressure monitoring assessed approximately 3 months postoperatively were compared to preoperative data. Results: All 21 enrolled patients underwent CAR. Carotid artery stenting was done in three patients with cardiovascular risk or anatomical difficult for carotid endarterectomy. The mean common carotid artery end-diastolic velocity improved significantly (P < 0.01) by 1.6-fold, from 10.8 ± 3.2 to 16.1 ± 7.1 cm/s. In 123I-MIBG scintigraphy, the heart-to-mediastinum (H/M) count ratio was significantly higher than preoperatively (from 2.66 ± 0.48 to 2.86 ± 0.56, P = 0.03). Holter ECG analysis revealed a significant decrease in the low-frequency/high-frequency (LF/HF) ratio compared to preoperatively (from 2.17 ± 1.20 to 1.62 ± 0.68, P = 0.04). These findings suggest decreased myocardial sympathetic activation. In echocardiography, the tissue Doppler-derived e’ increased, and E/e’ decreased significantly (P < 0.05) from 11.7 ± 5.1 to 10.1 ± 4.0, suggesting an improved left ventricular diastolic capacity. The mean 24-h and nighttime blood pressures were unchanged. Conclusions: CAR in patients with carotid stenosis may provide medium-term improvement in cardiac sympathetic nerve activity and left ventricular diastolic dysfunction. |
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| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 書誌情報 |
en : Cardiology Research 巻 13, 号 5, p. 289-296, 発行日 2022 |
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| 収録物識別子 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 19232829 | |||||
| 出版者 | ||||||
| 出版者 | Elmer Press | |||||
| 関連情報 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.14740/cr1402 | |||||
| 権利情報 | ||||||
| 権利情報 | © The authors | |||||
| 権利情報 | ||||||
| 権利情報 | Journal compilation © Cardiol Res and Elmer Press Inc™ | |||||
| 権利情報 | ||||||
| 権利情報 | www.cardiologyres.orgThis article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited | |||||
