{"created":"2023-07-25T10:25:28.278877+00:00","id":5831,"links":{},"metadata":{"_buckets":{"deposit":"d999f281-dfcd-433c-8f96-35454f47f9e0"},"_deposit":{"created_by":3,"id":"5831","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5831"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005831","sets":["611:939:940"]},"author_link":["16395","16397","16393","16396","16394"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"296","bibliographicPageStart":"289","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Cardiology Research"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Background: The carotid sinus baroreceptor reflex controls the neural regulation of blood pressure. Baroreceptor disorders due to carotid sinus atherosclerosis have detrimental cardiovascular effects. This study investigated the medium-term effects of carotid artery revascularization (CAR) on sympathetic and cardiac function and systemic blood pressure variability in patients with carotid artery stenosis.\nMethods: This study included 21 consecutive patients (median age 70 years, 18 men) with carotid artery stenosis scheduled for CAR. 123I metaiodobenzylguanidine (MIBG) scintigraphy, echocardiography, brain natriuretic peptide levels, 24-h Holter electrocardiography (ECG), and ambulatory blood pressure monitoring assessed approximately 3 months postoperatively were compared to preoperative data.\nResults: All 21 enrolled patients underwent CAR. Carotid artery stenting was done in three patients with cardiovascular risk or anatomical difficult for carotid endarterectomy. The mean common carotid artery end-diastolic velocity improved significantly (P < 0.01) by 1.6-fold, from 10.8 ± 3.2 to 16.1 ± 7.1 cm/s. In 123I-MIBG scintigraphy, the heart-to-mediastinum (H/M) count ratio was significantly higher than preoperatively (from 2.66 ± 0.48 to 2.86 ± 0.56, P = 0.03). Holter ECG analysis revealed a significant decrease in the low-frequency/high-frequency (LF/HF) ratio compared to preoperatively (from 2.17 ± 1.20 to 1.62 ± 0.68, P = 0.04). These findings suggest decreased myocardial sympathetic activation. In echocardiography, the tissue Doppler-derived e’ increased, and E/e’ decreased significantly (P < 0.05) from 11.7 ± 5.1 to 10.1 ± 4.0, suggesting an improved left ventricular diastolic capacity. The mean 24-h and nighttime blood pressures were unchanged.\nConclusions: CAR in patients with carotid stenosis may provide medium-term improvement in cardiac sympathetic nerve activity and left ventricular diastolic dysfunction.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elmer Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.14740/cr1402","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.14740/cr1402"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.14740/cr1402","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© The authors "},{"subitem_rights":" Journal compilation © Cardiol Res and Elmer Press Inc™ "},{"subitem_rights":" www.cardiologyres.orgThis article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"19232829","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Tsukasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Wakana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Teruki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-01-30"}],"displaytype":"detail","filename":"iA_2022_17.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_17.pdf","url":"https://air.repo.nii.ac.jp/record/5831/files/iA_2022_17.pdf"},"version_id":"4203fdf1-31d8-46bf-97b6-3e6e0b845aa0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Carotid sinus baroreceptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Carotid artery stenosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Carotid artery stenting","subitem_subject_scheme":"Other"},{"subitem_subject":"Carotid endarterectomy","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiac sympathetic nerve activity","subitem_subject_scheme":"Other"},{"subitem_subject":"HFpEF","subitem_subject_scheme":"Other"},{"subitem_subject":"123I-MIBG scintigraphy","subitem_subject_scheme":"Other"},{"subitem_subject":"Echocardiography","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-30"},"publish_date":"2023-01-30","publish_status":"0","recid":"5831","relation_version_is_last":true,"title":["Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T10:41:46.003609+00:00"}