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Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy
http://hdl.handle.net/10295/00006105
http://hdl.handle.net/10295/00006105b5503d04-c9b1-4eff-9ef9-df535c489b77
| 名前 / ファイル | ライセンス | アクション |
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iA_2022_13.pdf (5.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2022-12-07 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| アクセス権 | ||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||
| 作成者 |
Yakabe, Mitsutaka
× Yakabe, Mitsutaka
× Ogawa, Sumito
× Ota, Hidetaka
× Iijima, Katsuya
× Eto, Masato
× Ouchi, Yasuyoshi
× Akishita, Masahiro
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| 内容記述 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Background Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. \nMethods Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy. Results Serum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle RING finger 1 (MuRF1) expression and prevented muscle atrophy. HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice. Conclusion Systemic IL-6 affects MuRF1 expression and disuse-induced muscle atrophy. |
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| 言語 | en | |||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 書誌情報 |
en : PLoS ONE 巻 13, 号 1, 発行日 2018 |
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| 収録物識別子 | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 1932-6203 | |||||||||||||||||||
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| 出版者 | Public Library of Science | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.1371/journal.pone.0191318 | |||||||||||||||||||
| 言語 | ja | |||||||||||||||||||
| 権利情報 | ||||||||||||||||||||
| 権利情報 | © 2018 Yakabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||||||||||||||||
