{"created":"2023-07-25T10:25:27.668430+00:00","id":5817,"links":{},"metadata":{"_buckets":{"deposit":"cc87132e-6383-4009-b0d2-3f08b7523156"},"_deposit":{"created_by":15,"id":"5817","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5817"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005817","sets":["1489:1490:1491"]},"author_link":["16351","16352","16353","16354","16355","16356","16357"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Background\nInterleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear.\n\\nMethods\nTail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy.\nResults\nSerum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle RING finger 1 (MuRF1) expression and prevented muscle atrophy. HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice.\nConclusion\nSystemic IL-6 affects MuRF1 expression and disuse-induced muscle atrophy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science","subitem_publisher_language":"en"}]},"item_10001_relation_25":{"attribute_name":"関連情報","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0191318","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2018 Yakabe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited."}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1724099666130":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"作成者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yakabe, Mitsutaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Sumito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Hidetaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iijima, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eto, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ouchi, Yasuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16356","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akishita, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16357","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-07"}],"displaytype":"detail","filename":"iA_2022_13.pdf","filesize":[{"value":"5.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2022_13.pdf","url":"https://air.repo.nii.ac.jp/record/5817/files/iA_2022_13.pdf"},"version_id":"fb562fe2-a66b-41eb-ab9f-d0471689f800"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["1491"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-07"},"publish_date":"2022-12-07","publish_status":"0","recid":"5817","relation_version_is_last":true,"title":["Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-08-24T14:02:40.623375+00:00"}