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  1. 20 医学系研究科・医学部
  2. 20A 学術誌論文
  3. 20A1 雑誌掲載論文

Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas

http://hdl.handle.net/10295/00005864
http://hdl.handle.net/10295/00005864
5b66e69c-fdbe-4d8f-8b18-e387e6b3409e
名前 / ファイル ライセンス アクション
iA_2021_41.pdf iA_2021_41 (3.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-01-04
タイトル
タイトル Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas
言語 en
言語
言語 eng
主題
主題Scheme Other
主題 hypofractionated stereotactic radiotherapy
主題
主題Scheme Other
主題 long-term outcomes
主題
主題Scheme Other
主題 nonfunctioning pituitary adenomas
主題
主題Scheme Other
主題 optic chiasm
主題
主題Scheme Other
主題 optic nerve
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 HATA, Aiko

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en HATA, Aiko

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ODA, Masaya

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en ODA, Masaya

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ONO, Takahiro

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en ONO, Takahiro

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SUZUKI, Akira

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en SUZUKI, Akira

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HANYU, Noriaki

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TAKAHASHI, Masataka

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SASAJIMA, Toshio

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HASHIMOTO, Manabu

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NAKASE, Taizen

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SHIMIZU, Hiroaki

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内容記述
内容記述タイプ Abstract
内容記述 The efficacy of stereotactic radiotherapy (SRT) has been well established for postoperative residual and recurrent nonfunctioning pituitary adenomas (NFPAs). However, the risk of visual impairment due to SRT for lesions adjacent to the optic pathways remains a topic of debate. Herein, we evaluated the long-term clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) for perioptic NFPAs. From December 2002 to November 2015, 32 patients (18 males and 14 females; median age 63 years; range, 36–83 years) with residual or recurrent NFPAs abutting or displacing the optic nerve and/or chiasm (ONC) were treated with HFSRT. The median marginal dose was 31.3 Gy (range, 17.2–39.6) in 8 fractions (range, 6–15). Magnetic resonance imaging (MRI) and visual and hormonal examinations were performed before and after HFSRT. The median follow-up period was 99.5 months (range, 9–191). According to MRI findings at the last follow-up, the tumor size had decreased in 28 (88%) of 32 patients, was unchanged in 3 (9%), and had increased in 1 (3%). The successful tumor size control rate was 97%. Visual functions remained unchanged in 19 (60%) out of 32 patients, improved in 11 (34%), and deteriorated in 2 (6%). Two patients had deteriorated visual functions; no complications occurred because of the HFSRT. One patient developed hypopituitarism that required hormone replacement therapy. The result of this long-term follow-up study suggests that HFSRT is safe and effective for the treatment of NFPAs occurring adjacent to the ONC.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 Neurologia medico-chirurgica

巻 61, 号 7, p. 404-413, 発行日 2021
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1349-8029
出版者
出版者 The Japan Neurosurgical Society
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.2176/nmc.oa.2020-0378
権利情報
権利情報 © 2021 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License.
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