| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-01-04 |
| タイトル |
|
|
タイトル |
Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hypofractionated stereotactic radiotherapy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
long-term outcomes |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
nonfunctioning pituitary adenomas |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
optic chiasm |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
optic nerve |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
HATA, Aiko
ODA, Masaya
ONO, Takahiro
SUZUKI, Akira
HANYU, Noriaki
TAKAHASHI, Masataka
SASAJIMA, Toshio
HASHIMOTO, Manabu
NAKASE, Taizen
SHIMIZU, Hiroaki
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The efficacy of stereotactic radiotherapy (SRT) has been well established for postoperative residual and recurrent nonfunctioning pituitary adenomas (NFPAs). However, the risk of visual impairment due to SRT for lesions adjacent to the optic pathways remains a topic of debate. Herein, we evaluated the long-term clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) for perioptic NFPAs. From December 2002 to November 2015, 32 patients (18 males and 14 females; median age 63 years; range, 36–83 years) with residual or recurrent NFPAs abutting or displacing the optic nerve and/or chiasm (ONC) were treated with HFSRT. The median marginal dose was 31.3 Gy (range, 17.2–39.6) in 8 fractions (range, 6–15). Magnetic resonance imaging (MRI) and visual and hormonal examinations were performed before and after HFSRT. The median follow-up period was 99.5 months (range, 9–191). According to MRI findings at the last follow-up, the tumor size had decreased in 28 (88%) of 32 patients, was unchanged in 3 (9%), and had increased in 1 (3%). The successful tumor size control rate was 97%. Visual functions remained unchanged in 19 (60%) out of 32 patients, improved in 11 (34%), and deteriorated in 2 (6%). Two patients had deteriorated visual functions; no complications occurred because of the HFSRT. One patient developed hypopituitarism that required hormone replacement therapy. The result of this long-term follow-up study suggests that HFSRT is safe and effective for the treatment of NFPAs occurring adjacent to the ONC. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
Neurologia medico-chirurgica
巻 61,
号 7,
p. 404-413,
発行日 2021
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-8029 |
| 出版者 |
|
|
出版者 |
The Japan Neurosurgical Society |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.2176/nmc.oa.2020-0378 |
| 権利情報 |
|
|
権利情報 |
© 2021 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License. |
iA_2021_41 (3.0 MB)
