{"created":"2023-07-25T10:25:17.949493+00:00","id":5547,"links":{},"metadata":{"_buckets":{"deposit":"2c5a0f41-4a6b-4d2a-9127-fb845c4e96f8"},"_deposit":{"created_by":15,"id":"5547","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"5547"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00005547","sets":["611:939:940"]},"author_link":["15664","15662","15665","15657","15661","15658","15663","15653","15660","15659"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"413","bibliographicPageStart":"404","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Neurologia medico-chirurgica"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"The efficacy of stereotactic radiotherapy (SRT) has been well established for postoperative residual and recurrent nonfunctioning pituitary adenomas (NFPAs). However, the risk of visual impairment due to SRT for lesions adjacent to the optic pathways remains a topic of debate. Herein, we evaluated the long-term clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) for perioptic NFPAs. From December 2002 to November 2015, 32 patients (18 males and 14 females; median age 63 years; range, 36–83 years) with residual or recurrent NFPAs abutting or displacing the optic nerve and/or chiasm (ONC) were treated with HFSRT. The median marginal dose was 31.3 Gy (range, 17.2–39.6) in 8 fractions (range, 6–15). Magnetic resonance imaging (MRI) and visual and hormonal examinations were performed before and after HFSRT. The median follow-up period was 99.5 months (range, 9–191). According to MRI findings at the last follow-up, the tumor size had decreased in 28 (88%) of 32 patients, was unchanged in 3 (9%), and had increased in 1 (3%). The successful tumor size control rate was 97%. Visual functions remained unchanged in 19 (60%) out of 32 patients, improved in 11 (34%), and deteriorated in 2 (6%). Two patients had deteriorated visual functions; no complications occurred because of the HFSRT. One patient developed hypopituitarism that required hormone replacement therapy. The result of this long-term follow-up study suggests that HFSRT is safe and effective for the treatment of NFPAs occurring adjacent to the ONC.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Japan Neurosurgical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2176/nmc.oa.2020-0378","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2176/nmc.oa.2020-0378","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"© 2021 The Japan Neurosurgical Society This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-8029","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HATA, Aiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ODA, Masaya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ONO, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUZUKI, Akira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HANYU, Noriaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAKAHASHI, Masataka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SASAJIMA, Toshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HASHIMOTO, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKASE, Taizen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Hiroaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-01-04"}],"displaytype":"detail","filename":"iA_2021_41.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","license_note":"CC BY-NC-ND 4.0","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"iA_2021_41","url":"https://air.repo.nii.ac.jp/record/5547/files/iA_2021_41.pdf"},"version_id":"5bbd469f-783c-4413-a92c-4b8a30fedc55"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hypofractionated stereotactic radiotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"long-term outcomes","subitem_subject_scheme":"Other"},{"subitem_subject":"nonfunctioning pituitary adenomas","subitem_subject_scheme":"Other"},{"subitem_subject":"optic chiasm","subitem_subject_scheme":"Other"},{"subitem_subject":"optic nerve","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas"}]},"item_type_id":"10001","owner":"15","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-01-04"},"publish_date":"2022-01-04","publish_status":"0","recid":"5547","relation_version_is_last":true,"title":["Long-term Outcomes of Hypofractionated Stereotactic Radiotherapy for the Treatment of Perioptic Nonfunctioning Pituitary Adenomas"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-07-25T10:45:47.584896+00:00"}