| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-11-13 |
| タイトル |
|
|
タイトル |
Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Muscle strength |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle fatigue |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
muscle-related gene |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
eldecalcitol |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00003438 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Kinoshita, Hayato
Miyakoshi, Naohisa
Kasukawa, Yuji
Sakai, Sadaoki
Shiraishi, Ayako
Segawa, Toyohito
Ohuchi, Kentaro
Fujii, Masashi
Sato, Chie
Shimada, Yoichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Glucocorticoid causes secondary osteoporosis and myopathy, characterized by type II muscle fiber atrophy. We examined whether a new vitamin D3 analog, eldecalcitol, could inhibit glucocorticoid-induced osteopenia or myopathy in rats and determined the effects of prednisolone (PSL) and/or eldecalcitol on muscle-related gene expression. Six-month-old female Wistar rats were randomized into four groups: PSL group (10 mg/kg PSL); E group (0.05 µg/kg eldecalcitol); PSL + E group; and control group. PSL, eldecalcitol, and vehicles were administered daily for 2 or 4 weeks. Right calf muscle strength, muscle fatigue, cross-sectional areas (CSAs) of left tibialis anterior muscle fibers, and bone mineral density (BMD) were measured following administration. Pax7, MyoD, and myogenin mRNA levels in gastrocnemius muscles were also determined. The PSL + E group muscle strength was significantly higher than that of the PSL group (p < 0.05) after 4 but not 2 weeks. There was no significant difference in muscle fatigue between the groups at 2 or 4 weeks. The CSAs of type II muscle fibers were significantly larger in the E group and PSL + E group than the PSL group at 4 weeks (p = 0.0093, p = 0.0443, respectively). Eldecalcitol treatment for 4 weeks maintained the same BMD as the PSL + E group. After 2 but not 4 weeks, eldecalcitol treatment significantly increased Pax7 and myogenin mRNA expression in gastrocnemius muscle, while PSL also stimulated myogenin expression. Eldecalcitol appears to increase muscle volume and protect against femur BMD loss in PSL-administered rats. It may also stimulate myoblast differentiation into early myotubes. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
秋田大学審査学位論文の著者稿, 学位名：博士（医学）, 学位授与年月日：20160322, 学位授与番号：11401甲第1153号 |
|
言語 |
ja |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 書誌情報 |
en : Journal of Bone and Mineral Metabolism
巻 34,
号 2,
p. 171-178,
発行日 2016
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14355604 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11626610 |
| 出版者 |
|
|
出版者 |
Springer |
|
言語 |
en |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00774-015-0664-4 |
| 権利者情報 |
|
|
|
権利者名 |
Springer Nature |
|
|
言語 |
en |
ihakukou1153.pdf (306.9 kB)
