{"created":"2023-07-25T10:23:25.966143+00:00","id":3073,"links":{},"metadata":{"_buckets":{"deposit":"78357313-ddf3-49ff-88dc-0706c87d7f47"},"_deposit":{"created_by":3,"id":"3073","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3073"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00003073","sets":["611:939:940"]},"author_link":["10810","10814","10809","10811","10816","10813","10812","10815","10807","10808"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"178","bibliographicPageStart":"171","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Journal of Bone and Mineral Metabolism"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Glucocorticoid causes secondary osteoporosis and myopathy, characterized by type II   muscle fiber  atrophy. We examined whether a new vitamin D3 analog, eldecalcitol, could inhibit  glucocorticoid-induced osteopenia or myopathy in rats and determined the effects of   prednisolone  (PSL) and/or eldecalcitol on muscle-related gene expression. Six-month-old female Wistar rats were randomized into four groups: PSL group (10 mg/kg   PSL); E  group (0.05 µg/kg eldecalcitol); PSL + E group; and control group. PSL, eldecalcitol,   and vehicles  were administered daily for 2 or 4 weeks. Right calf muscle strength, muscle fatigue,  cross-sectional areas (CSAs) of left tibialis anterior muscle fibers, and bone mineral   density  (BMD) were measured following administration. Pax7, MyoD, and myogenin mRNA levels in   gastrocnemius  muscles were also determined. The PSL + E group muscle strength was significantly higher than that of the PSL group   (p < 0.05)  after 4 but not 2 weeks. There was no significant difference in muscle fatigue between   the groups  at 2 or 4 weeks. The CSAs of type II muscle fibers were significantly larger in the E   group and PSL  + E group than the PSL group at 4 weeks (p = 0.0093, p = 0.0443, respectively). Eldecalcitol treatment for 4 weeks maintained the   same BMD as  the PSL + E group. After 2 but not 4 weeks, eldecalcitol treatment significantly   increased Pax7 and  myogenin mRNA expression in gastrocnemius muscle, while PSL also stimulated myogenin   expression.  Eldecalcitol appears to increase muscle volume and protect against femur BMD loss in  PSL-administered rats. It may also stimulate myoblast differentiation into early   myotubes.   ","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.20569/00003438","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1007/s00774-015-0664-4","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_25":{"attribute_name":"関連リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://link.springer.com/article/10.1007%2Fs00774-015-0664-4"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://link.springer.com/article/10.1007%2Fs00774-015-0664-4","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"Springer"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11626610","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14355604","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文の著者稿, 学位名：博士（医学）, 学位授与年月日：20160322, 学位授与番号：11401甲第1153号"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kinoshita, Hayato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyakoshi, Naohisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kasukawa, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Sadaoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiraishi, Ayako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Segawa, Toyohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohuchi, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujii, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Chie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Yoichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-13"}],"displaytype":"detail","filename":"ihakukou1153.pdf","filesize":[{"value":"306.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ihakukou1153.pdf","url":"https://air.repo.nii.ac.jp/record/3073/files/ihakukou1153.pdf"},"version_id":"f56518b9-4df2-451c-8137-b489c3a7d49c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Muscle strength","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle fatigue","subitem_subject_scheme":"Other"},{"subitem_subject":"muscle-related gene","subitem_subject_scheme":"Other"},{"subitem_subject":"bone","subitem_subject_scheme":"Other"},{"subitem_subject":"eldecalcitol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-13"},"publish_date":"2017-11-13","publish_status":"0","recid":"3073","relation_version_is_last":true,"title":["Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:27:20.827207+00:00"}