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STELLATE CELLS (VITAMIN A-STORING CELLS) ARE THE PRIMARY SITE OF COLLAGEN SYNTHESIS IN NON-PARENCHYMAL CELLS IN THE LIVER
http://hdl.handle.net/10295/3065
http://hdl.handle.net/10295/306518be6f0e-5d31-4c1a-89e7-248fcd5f6a49
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
senoo7.pdf (2.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-04-20 | |||||
| タイトル | ||||||
| タイトル | STELLATE CELLS (VITAMIN A-STORING CELLS) ARE THE PRIMARY SITE OF COLLAGEN SYNTHESIS IN NON-PARENCHYMAL CELLS IN THE LIVER | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 作成者 |
SENOO, Haruki
× SENOO, Haruki× HATA, Ryu-ichiro× NAGAI, Yutaka× WAKE, Kenjiro |
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| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A cell fraction enriched with lipid droplet-containing cells (perisinusoidal stellate cells, vitamin A-storing cells, or fat-storing cells), and freed from contamination ofparenchymal cells, was prepared by low speed centrifugation followed by Percoll density gradient centrifugation. Cells in this fraction were found to take up and store the largest amount of vitamin A per cell among the liver cells including parenchymal cells, when [3H]retinol was injected through the portal vein of rats. Analysis of collagen production by this fraction as well as another non-parenchymal cell fraction (rich in Kupffer cells and endothelial cells) in culture has shown that only the stellate cell-rich fraction produced collagen which was composed of type I (88.2%), type III (10.4%) and membranous type (1.4%). There was no indication of collagen production in other non-parenchymal cell fractions under the experimental conditions employed. These results indicate that, among non-parenchymal cells, lipid droplet-containing cells or stellate cells are primarily responsible for collagen production in the liver. | |||||
| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 書誌情報 |
en : Biomedical Research 巻 5, 号 6, p. 451-458, 発行日 1984-01-01 |
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| 収録物識別子 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03866106 | |||||
| 収録物識別子 | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00009294 | |||||
| 出版者 | ||||||
| 出版者 | Biomedical Research Foundation | |||||
| 言語 | en | |||||
| 関連情報 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.2220/biomedres.5.451 | |||||
