@article{oai:air.repo.nii.ac.jp:00002705,
 author = {SENOO, Haruki and HATA, Ryu-ichiro and NAGAI, Yutaka and WAKE, Kenjiro},
 issue = {6},
 journal = {Biomedical Research},
 month = {Jan},
 note = {A cell fraction enriched with lipid droplet-containing cells (perisinusoidal stellate cells,
vitamin A-storing cells, or fat-storing cells), and freed from contamination ofparenchymal
cells, was prepared by low speed centrifugation followed by Percoll density gradient
centrifugation. Cells in this fraction were found to take up and store the largest amount
of vitamin A per cell among the liver cells including parenchymal cells, when [3H]retinol
was injected through the portal vein of rats. Analysis of collagen production by this fraction
as well as another non-parenchymal cell fraction (rich in Kupffer cells and endothelial
cells) in culture has shown that only the stellate cell-rich fraction produced collagen
which was composed of type I (88.2%), type III (10.4%) and membranous type
(1.4%). There was no indication of collagen production in other non-parenchymal cell
fractions under the experimental conditions employed. These results indicate that,
among non-parenchymal cells, lipid droplet-containing cells or stellate cells are primarily
responsible for collagen production in the liver.},
 pages = {451--458},
 title = {STELLATE CELLS (VITAMIN A-STORING CELLS) ARE THE PRIMARY SITE OF COLLAGEN SYNTHESIS IN NON-PARENCHYMAL CELLS IN THE LIVER},
 volume = {5},
 year = {1984}
}