| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-04-20 |
| タイトル |
|
|
タイトル |
肝臓星細胞研究の新展開 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
New Development in the Research of Hepatic Stellate Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatic stellate cells |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vitamin A |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
retinol-binding protein |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
extracellular matrix |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
L-ascorbic acid 2-phosphate |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
SENOO, Haruki
IMAI, Katsuyuki
MATANO, Yoshikazu
SATO, Mitsuru
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Hepatic stellate cells（interstitial cells,vitaminA-storing cells,lipocytes， fat-storing cells）exist in the perisinusoidal space（space of Disse）of the hepatic lobule， and store 80％ of vitamin in the whole body as retinyl palmitate in lipid droplets in the cytoplasm ln physiological conditions, these cells play pivotal roles in the regulation of vitamin homeostasis； they express specific receptors for retinol-binding protein（RBP),a carrier protein specific for retinol, on their cell surface, and take up the complex of retinol and RBP by receptor-mediated endocytosis Whereas, in pathological conditions such as liver fibrosis，these cells lose retinoids，and synthesize a large amount of extracellular matrix（ECM）components including collagen, proteoglycan and adhesive glycoproteins.Morphology of these cells also changes from the star-shaped stellate cells to that of fibroblasts or myofibroblasts.Three-dimensional structure of ECM components reversibly regulates the morphology, proliferation, and functions of the hepatic stellate cells、These regulations are mediated by direct cellular adhesion to ECM, matrix adhesion signals,and modulation of cytoskeletons．“Extrahepatic stellate cells'，that distribute in various organs except the liver also play pivotal roles in vitaminA homeostasis、L-Ascorbic acid2-phosphate（along-actingv itaminC derivative）can stimulate proliferation of the stellate cells and promote three-dimensional liver-like structure in the co-culture system of hepatic parenchymal cells and mesenchymal cells． |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 25,
号 2,
p. 31-51,
発行日 1998-01-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
senoo6.pdf (7.4 MB)
