{"created":"2023-07-25T10:23:06.359099+00:00","id":2704,"links":{},"metadata":{"_buckets":{"deposit":"29dcff8e-d53e-4cc7-8273-7e3b54dd68d3"},"_deposit":{"created_by":3,"id":"2704","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2704"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002704","sets":["611:862:863:942"]},"author_link":["9954","9955","9953","9952"],"item_10001_alternative_title_1":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"New Development in the Research of Hepatic Stellate Cells"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"51","bibliographicPageStart":"31","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Hepatic　stellate　cells（interstitial　cells,vitaminA-storing　cells,lipocytes，\nfat-storing　cells）exist　in　the　perisinusoidal　space（space　of　Disse）of　the　hepatic　lobule，\nand　store　80％　of　vitamin　in　the　whole　body　as　retinyl　palmitate　in　lipid　droplets　in\nthe　cytoplasm　ln　physiological　conditions,　these　cells　play　pivotal　roles　in　the　regulation　of　vitamin　homeostasis；\nthey　express　specific　receptors　for　retinol-binding\nprotein（RBP),a　carrier　protein　specific　for　retinol,　on　their　cell　surface,　and　take　up　the　complex　of　retinol　and　RBP　by　receptor-mediated　endocytosis　Whereas,　in　pathological　conditions　such　as　liver　fibrosis，these　cells　lose　retinoids，and　synthesize　a　large　amount　of　extracellular　matrix（ECM）components　including　collagen,　proteoglycan　and　adhesive　glycoproteins.Morphology　of　these　cells　also　changes　from　the　star-shaped　stellate　cells　to　that　of　fibroblasts　or　myofibroblasts.Three-dimensional　structure　of　ECM　components　reversibly　regulates　the　morphology,　proliferation,　and　functions　of　the　hepatic　stellate　cells、These　regulations　are　mediated　by　direct　cellular　adhesion　to　ECM,　matrix　adhesion　signals,and　modulation　of　cytoskeletons．“Extrahepatic　stellate　cells'，that　distribute　in　various　organs　except　the　liver　also　play　pivotal　roles　in　vitaminA　homeostasis、L-Ascorbic　acid2-phosphate（along-actingv　itaminC　derivative）can　stimulate　proliferation　of　the　stellate　cells　and　promote　three-dimensional　liver-like　structure　in　the　co-culture　system　of　hepatic　parenchymal　cells　and　mesenchymal　cells．","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SENOO, Haruki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAI, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATANO, Yoshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SATO, Mitsuru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"senoo6.pdf","filesize":[{"value":"7.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"senoo6.pdf","url":"https://air.repo.nii.ac.jp/record/2704/files/senoo6.pdf"},"version_id":"fa6ca362-3293-4566-96cb-6d03280117ef"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatic stellate cells","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin A","subitem_subject_scheme":"Other"},{"subitem_subject":"retinol-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix","subitem_subject_scheme":"Other"},{"subitem_subject":"L-ascorbic acid 2-phosphate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝臓星細胞研究の新展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝臓星細胞研究の新展開"}]},"item_type_id":"10001","owner":"3","path":["942"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-20"},"publish_date":"2016-04-20","publish_status":"0","recid":"2704","relation_version_is_last":true,"title":["肝臓星細胞研究の新展開"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:32:11.805382+00:00"}