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REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.
http://hdl.handle.net/10295/2884
http://hdl.handle.net/10295/2884a8416524-e9d9-413a-8557-9ded0adea762
名前 / ファイル | ライセンス | アクション |
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本文 (900.0 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-06-16 | |||||
タイトル | ||||||
タイトル | REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PD-L1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | REG Iα | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | esophageal cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
別タイトル | ||||||
その他のタイトル | 食道扁平上皮癌細胞において REG Iαは PD-L1 の発現を誘導する | |||||
著者 |
脇田, 晃行
× 脇田, 晃行× WAKITA, Akiyuki |
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内容記述(抄録) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. Programmed death-1 ligand(PD-L1) is a negative regulator of T cell activation thought to play an important role in tumor evasion from host immunity. In the present study, we tested the hypothesis that the pro-survival effects of REG Iα in cancer reflect enhanced expression of PD-L1. We found that PD-L1 mRNA expression tended to correspond to REG Iα mRNA levels in esophageal squamous cancer cells, and that REG Iα expression significantly increased expression of both PD-L1 mRNA and protein in TE-5 and TE-9 squamous esophageal cancer cells transfected with REG Iα. In addition, immunohistochemical analysis of squamous cell esophageal cancer specimens revealed that the spatial distribution of PD-L1 expression corresponded to that of REG Iα. These findings suggest that REG Iα may suppress antitumor immunity by inducing PD-L1 expression. |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
書誌情報 | 発行日 2015-06-01 | |||||
備考 | ||||||
秋田大学審査学位論文(秋田医学,41(3/4),p121-p128掲載論文の著者最終稿) | ||||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 11401 | |||||
学位授与機関名 | 秋田大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-03-22 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第1127号 |