{"created":"2023-07-25T10:22:59.781885+00:00","id":2556,"links":{},"metadata":{"_buckets":{"deposit":"191fb09d-500d-4a0c-a44c-b02fe0bdd6a2"},"_deposit":{"created_by":3,"id":"2556","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2556"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002556","sets":["611:968:969:1049"]},"author_link":["9413","9412"],"item_10006_alternative_title_32":{"attribute_name":"別タイトル","attribute_value_mlt":[{"subitem_alternative_title":"食道扁平上皮癌細胞において REG Iαは PD-L1 の発現を誘導する"}]},"item_10006_biblio_info_34":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-01","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_10006_date_granted_41":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-22"}]},"item_10006_degree_grantor_40":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"秋田大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_39":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_10006_description_27":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Regenerating gene (REG)Iα is known to contribute to carcinogenesis and to be associated with a poor prognosis in various cancers. \nProgrammed death-1 ligand(PD-L1) is a negative regulator of T cell activation thought to play an important role in tumor evasion from host immunity.\nIn the present study, we tested the hypothesis that the pro-survival effects of REG Iα in cancer reflect enhanced expression of PD-L1.\nWe found that PD-L1 mRNA expression tended to correspond to REG Iα \nmRNA levels in esophageal squamous cancer cells, and that REG Iα expression significantly increased expression of both PD-L1 mRNA and protein in TE-5 and TE-9 squamous esophageal cancer cells transfected with REG Iα.\nIn addition, immunohistochemical analysis of squamous cell esophageal cancer specimens revealed that the spatial distribution of PD-L1 expression corresponded to that of REG Iα. These findings suggest that REG Iα may suppress antitumor immunity by inducing PD-L1 expression.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_42":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1127号"}]},"item_10006_text_36":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文（秋田医学,41(3/4),p121-p128掲載論文の著者最終稿）"}]},"item_10006_version_type_35":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"脇田, 晃行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"WAKITA, Akiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1127.pdf","filesize":[{"value":"900.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://air.repo.nii.ac.jp/record/2556/files/ihakukou1127.pdf"},"version_id":"214508ec-2888-48d6-bf7b-3cc48a4ed006"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PD-L1","subitem_subject_scheme":"Other"},{"subitem_subject":"REG Iα","subitem_subject_scheme":"Other"},{"subitem_subject":"esophageal cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells."}]},"item_type_id":"10006","owner":"3","path":["1049"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-06-16"},"publish_date":"2015-06-16","publish_status":"0","recid":"2556","relation_version_is_last":true,"title":["REG Iα Promotes PD-L1 Expression in Esophageal Cancer Cells."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:32:25.508681+00:00"}