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Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset
http://hdl.handle.net/10295/2850
http://hdl.handle.net/10295/28504f01fb66-da10-41f8-a1d2-5c0c0e6d1806
| 名前 / ファイル | ライセンス | アクション |
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内容要旨及び審査結果要旨 (764.7 kB)
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本文 (1.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2015-06-12 | |||||||||
| タイトル | ||||||||||
| タイトル | Noninvasive detection of sleep/wake changes and cataplexy -like behaviors in orexin/ataxin-3 transgenicnarcoleptic mice across the disease onset | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 別タイトル | ||||||||||
| その他のタイトル | 発症前後のナルコレプシーモデルマウスにおける睡眠覚醒変化とカタプレキシー様行動の非侵襲的解析 | |||||||||
| 作成者 |
佐藤, 雅俊
× 佐藤, 雅俊
× SATO, Masatoshi
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| 内容記述（抄録） | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Sleep and behavioral monitoring of young mice is necessary for understating the progress of these symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep of newborn mice using a simple piezoelectric transducer (PZT). Using this system, we have succeeded to detect age-dependent occurrences and changes in sleep fragmentation of orexin/ataxin-3 narcoleptic mice (a narcoleptic mouse of model of postnatal hypocretin/orexin cell death) across the disease onset. We also detected REM sleep/cataplexy patterns (i.e., immobility with clear heart bests [IMHB] signals due to the flaccid posture) by the PZT system, and found that sudden onset of REM sleep-like episodes specifically occur in narcoleptic, but not in wild type mice, suggesting that these episodes are likely to be cataplexy. In contrast, gradual onset of IMHB likely to reflect occurrence of REM sleep. In summary, we have shown that the PZT system is useful as a noninvasive sleep and behavior monitoring system to analyze the developmental aspects of sleep and movement disorders in mice models. |
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| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | info:doi/10.1016/j.expneurol.2014.08.004 | |||||||||
| 書誌情報 | 発行日 2015-06-01 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 秋田大学 | |||||||||
| 著作権等 | ||||||||||
| 権利情報 | Elsevier | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 11401 | |||||||||
| 学位授与機関名 | 秋田大学 | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2015-03-22 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第1110号 | |||||||||
