| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-06-27 |
| タイトル |
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|
タイトル |
Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Contrast-induced acute kidney injury |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Coronary angiography |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Liver-type fatty acid-binding protein |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Remote ischemic preconditioning |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Igarashi, Gen
Iino, Kenji
Watanabe, Hiroyuki
Ito, Hiroshi
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| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Although remote ischemic preconditioning (RIPC) is shown to preserve kidney function in patients at high risk of contrast-induced acute kidney injury (CI-AKI), the effect in patients at low-moderate risk remains unknown. The preventive effects of RIPC in patients not at high risk of CI-AKI were examined, and biomarkers with anticipated roles in renal protection via RIPC investigated. Methods and Results: Sixty patients who had moderate chronic kidney disease and who underwent angiography were randomly assigned to the control (n=30) or RIPC (intermittent arm ischemia, n=30) group. The baseline characteristics in the 2 groups did not differ significantly. CI-AKI was evaluated by measuring urinary liver-type fatty acidbinding protein (L-FABP). Biomarkers were measured before and 24 and 48 h after angiography. Twenty-four hours after angiography, the percent change in urinary L-FABP level in the RIPC group was significantly smaller than in the control group (41.3±15.6 vs. 159±34.1%, P=0.003). L-FABP-based CI-AKI developed in 8 control patients (26.9%) vs. only 2 patients in the RIPC group (7.7%), suggesting that RIPC prevents CI-AKI. Factors contributing to CI-AKI were analyzed. Neither high-sensitivity C-reactive protein nor pentraxine-3 level differed significantly between the 2 groups, while the percent change in asymmetrical dimethy larginine (ADMA) level and blood derivatives of reactive oxidative metabolite levels were significantly smaller in the RIPC group. Conclusions: RIPC alleviates CI-AKI in patients at low-moderate risk. This effect might be mediated partly by decreasing oxidative stress and plasma ADMA level. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
秋田大学審査学位論文の「Circulation Journal」掲載版 |
|
言語 |
ja |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Circulation Journal
巻 77,
号 12,
p. 3037-3044,
発行日 2013-11-25
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| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13469843 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11591968 |
| 出版者 |
|
|
出版者 |
Japanese Circulation Society |
|
言語 |
en |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1253/circj.CJ-13-0171 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
Japanese Circulation Society |
ihakukou1074.pdf (921.4 kB)
