{"created":"2023-07-25T10:22:48.676050+00:00","id":2301,"links":{},"metadata":{"_buckets":{"deposit":"0288d0ba-48fc-4aab-92c3-254cd0278a71"},"_deposit":{"created_by":3,"id":"2301","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2301"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002301","sets":["611:939:940"]},"author_link":["8642","8643","8644","8641"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"3044","bibliographicPageStart":"3037","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"Circulation Journal"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Background: Although remote ischemic preconditioning (RIPC) is shown to preserve kidney function in patients at high risk of contrast-induced acute kidney injury (CI-AKI), the effect in patients at low-moderate risk remains unknown. The preventive effects of RIPC in patients not at high risk of CI-AKI were examined, and biomarkers with anticipated roles in renal protection via RIPC investigated. Methods and Results: Sixty patients who had moderate chronic kidney disease and who underwent angiography were randomly assigned to the control (n=30) or RIPC (intermittent arm ischemia, n=30) group. The baseline characteristics in the 2 groups did not differ significantly. CI-AKI was evaluated by measuring urinary liver-type fatty acidbinding protein (L-FABP). Biomarkers were measured before and 24 and 48 h after angiography. Twenty-four hours after angiography, the percent change in urinary L-FABP level in the RIPC group was significantly smaller than in the control group (41.3±15.6 vs. 159±34.1%, P=0.003). L-FABP-based CI-AKI developed in 8 control patients (26.9%) vs. only 2 patients in the RIPC group (7.7%), suggesting that RIPC prevents CI-AKI. Factors contributing to CI-AKI were analyzed. Neither high-sensitivity C-reactive protein nor pentraxine-3 level differed significantly between the 2 groups, while the percent change in asymmetrical dimethy larginine (ADMA) level and blood derivatives of reactive oxidative metabolite levels were significantly smaller in the RIPC group. Conclusions: RIPC alleviates CI-AKI in patients at low-moderate risk. This effect might be mediated partly by decreasing oxidative stress and plasma ADMA level.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Circulation Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1253/circj.CJ-13-0171","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"著作権等","attribute_value_mlt":[{"subitem_rights":"Japanese Circulation Society"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11591968","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13469843","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_text_value":"秋田大学審査学位論文の「Circulation Journal」掲載版"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Igarashi, Gen"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iino, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"ihakukou1074.pdf","filesize":[{"value":"921.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ihakukou1074.pdf","url":"https://air.repo.nii.ac.jp/record/2301/files/ihakukou1074.pdf"},"version_id":"e898f101-d495-41de-ae80-49007e508712"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Contrast-induced acute kidney injury","subitem_subject_scheme":"Other"},{"subitem_subject":"Coronary angiography","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver-type fatty acid-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"Remote ischemic preconditioning","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease"}]},"item_type_id":"10001","owner":"3","path":["940"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-27"},"publish_date":"2014-06-27","publish_status":"0","recid":"2301","relation_version_is_last":true,"title":["Remote Ischemic Pre-Conditioning Alleviates Contrast Induced Acute Kidney Injury in Patients With Moderate Chronic Kidney Disease"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:32:56.608774+00:00"}