| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-05-29 |
| タイトル |
|
|
タイトル |
AGE- RELATED CHANGES IN ELECTROPHYSIOLOGICAL PROPERTIES CBA/N MICE UTRICULAR TYPE II HAIR CELLS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vestibular organ |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
utricle, hair cell |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
voltage-gated conductance |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inner-ear aging |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Koizumi, Kou
Omi, Eigo
Angunsri, Nakarin
Honda, Kohei
Ono, Kyoichi
Ishikawa, Kazuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective This study investigated vestibular functional declination with age, leading to age-related deterioration of balance function. It has been shown that the impaired vestibular function is derived from structural and/or functional degeneration of vestibular hair cells. Methods We quantitatively analyzed the number of hair cells in the utricle of CBA/N mice at 2 different ages (5 weeks old and 26 weeks old) using immunohistochemistry. In addition, electrophysiological properties of type II hair cells were evaluated by the patch clamp method. Results We found a significant difference in the number of hair cells between the two groups, i.e., the number of hair cells was significantly less in the adult group than in the young group. Electrophysiological experiments revealed that the current density of the delayed rectifier K^+ current was significantly lower in adult mice than in young mice, with little change in activation kinetics. Conclusions These findings suggest that not only hair cell loss but also alterations in hair cell functions, resulting from aging, is involved in balance dysfunction. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 39,
号 2,
p. 81-87,
発行日 2013-02-28
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai39(81).pdf (1.0 MB)
