{"created":"2023-07-25T10:22:36.326799+00:00","id":2016,"links":{},"metadata":{"_buckets":{"deposit":"1884842d-711e-48c1-ac21-938e2ceee2b3"},"_deposit":{"created_by":3,"id":"2016","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2016"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002016","sets":["611:862:863:937"]},"author_link":["7559","7563","7560","7558","7561","7562"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"87","bibliographicPageStart":"81","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"Objective  This study investigated vestibular functional declination with age, leading to age-related deterioration of balance function. It has been shown that the impaired vestibular function is derived from structural and/or functional degeneration of vestibular hair cells. Methods  We quantitatively analyzed the number of hair cells in the utricle of CBA/N mice at 2 different ages (5 weeks old and 26 weeks old) using immunohistochemistry. In addition, electrophysiological properties of type II hair cells were evaluated by the patch clamp method. Results  We found a significant difference in the number of hair cells between the two groups, i.e., the number of hair cells was significantly less in the adult group than in the young group. Electrophysiological experiments revealed that the current density of the delayed rectifier K^+ current was significantly lower in adult mice than in young mice, with little change in activation kinetics. Conclusions  These findings suggest that not only hair cell loss but also alterations in hair cell functions, resulting from aging, is involved in balance dysfunction.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Kou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Omi, Eigo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Angunsri, Nakarin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Honda, Kohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ono, Kyoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai39(81).pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai39(81).pdf","url":"https://air.repo.nii.ac.jp/record/2016/files/akitai39(81).pdf"},"version_id":"d9668eab-2557-48b7-b70f-e545f6ebf06a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vestibular organ","subitem_subject_scheme":"Other"},{"subitem_subject":"utricle, hair cell","subitem_subject_scheme":"Other"},{"subitem_subject":"voltage-gated conductance","subitem_subject_scheme":"Other"},{"subitem_subject":"inner-ear aging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"AGE- RELATED CHANGES IN ELECTROPHYSIOLOGICAL PROPERTIES CBA/N MICE UTRICULAR TYPE II HAIR CELLS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AGE- RELATED CHANGES IN ELECTROPHYSIOLOGICAL PROPERTIES CBA/N MICE UTRICULAR TYPE II HAIR CELLS"}]},"item_type_id":"10001","owner":"3","path":["937"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-29"},"publish_date":"2013-05-29","publish_status":"0","recid":"2016","relation_version_is_last":true,"title":["AGE- RELATED CHANGES IN ELECTROPHYSIOLOGICAL PROPERTIES CBA/N MICE UTRICULAR TYPE II HAIR CELLS"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:29.573295+00:00"}