| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-05-29 |
| タイトル |
|
|
タイトル |
C-REACTIVE PROTEIN INHIBITS CELL MIGRATION AND ENHANCES EXPRESSION OF E-CADHERIN IN MURINE SQUAMOUS CELL CARCINOMA CELLS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
C-reactive protein |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
E-cadherin |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
migration |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
epithelial-mesenchymal transition |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Sasaki, Tomohiko
Motoyama, Satoru
Sato, Yusuke
Yoshino, Kei
Saito, Hajime
Minamiya, Yoshihiro
Ogawa, Jun-ichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
C-reactive protein (CRP) is widely used as a biomarker of inflammation, though its functions are not fully understood. In the present study, we hypothesized that CRP reduces cancer cell invasion and migration by enhancing the expression of E-cadherin. NR-S1M cells, a murine squamous cell carcinoma line, were incubated for 48 h or 72 h with or without 10 or 50 μg/ml recombinant mouse CRP. Subsequent counts of viable cells showed that CRP had no significant effect on NR-S1M cell proliferation, nor did it affect invasion by the cells across a basement membrane matrix in Boyden chamber assays. By contrast, wound healing assays showed that CRP significantly weakened the migration potential of the cells. Moreover, Western and immunohistochemical analyses showed that CRP induced a corresponding increase in E-cadherin expression. These findings suggest that CRP may inhibit cancer cell migration, and thus metastasis, by strengthening cell-cell adhesion through increased E-cadherin expression. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 39,
号 2,
p. 45-51,
発行日 2013-02-28
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai39(45).pdf (903.5 kB)
