{"created":"2023-07-25T10:22:36.148087+00:00","id":2012,"links":{},"metadata":{"_buckets":{"deposit":"8bf57cd9-c98b-4565-a674-0587ac5aaa75"},"_deposit":{"created_by":3,"id":"2012","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2012"},"status":"published"},"_oai":{"id":"oai:air.repo.nii.ac.jp:00002012","sets":["611:862:863:937"]},"author_link":["7534","7535","7530","7533","7532","7531","7536"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"51","bibliographicPageStart":"45","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"秋田医学"}]}]},"item_10001_description_5":{"attribute_name":"内容記述（抄録）","attribute_value_mlt":[{"subitem_description":"C-reactive protein (CRP) is widely used as a biomarker of inflammation, though its functions are not fully understood. In the present study, we hypothesized that CRP reduces cancer cell invasion and migration by enhancing the expression of E-cadherin. NR-S1M cells, a murine squamous cell carcinoma line, were incubated for 48 h or 72 h with or without 10 or 50 μg/ml recombinant mouse CRP. Subsequent counts of viable cells showed that CRP had no significant effect on NR-S1M cell proliferation, nor did it affect invasion by the cells across a basement membrane matrix in Boyden chamber assays. By contrast, wound healing assays showed that CRP significantly weakened the migration potential of the cells. Moreover, Western and immunohistochemical analyses showed that CRP induced a corresponding increase in E-cadherin expression. These findings suggest that CRP may inhibit cancer cell migration, and thus metastasis, by strengthening cell-cell adhesion through increased E-cadherin expression.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"秋田医学会"}]},"item_10001_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00009294","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866106","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Tomohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motoyama, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Yusuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshino, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Minamiya, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Jun-ichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"akitai39(45).pdf","filesize":[{"value":"903.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"akitai39(45).pdf","url":"https://air.repo.nii.ac.jp/record/2012/files/akitai39(45).pdf"},"version_id":"b7507c19-af49-48db-b8a3-7320db3f3274"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C-reactive protein","subitem_subject_scheme":"Other"},{"subitem_subject":"E-cadherin","subitem_subject_scheme":"Other"},{"subitem_subject":"migration","subitem_subject_scheme":"Other"},{"subitem_subject":"epithelial-mesenchymal transition","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"C-REACTIVE PROTEIN INHIBITS CELL MIGRATION AND ENHANCES EXPRESSION OF E-CADHERIN IN MURINE SQUAMOUS CELL CARCINOMA CELLS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"C-REACTIVE PROTEIN INHIBITS CELL MIGRATION AND ENHANCES EXPRESSION OF E-CADHERIN IN MURINE SQUAMOUS CELL CARCINOMA CELLS"}]},"item_type_id":"10001","owner":"3","path":["937"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-05-29"},"publish_date":"2013-05-29","publish_status":"0","recid":"2012","relation_version_is_last":true,"title":["C-REACTIVE PROTEIN INHIBITS CELL MIGRATION AND ENHANCES EXPRESSION OF E-CADHERIN IN MURINE SQUAMOUS CELL CARCINOMA CELLS"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:33:33.928374+00:00"}