| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-19 |
| タイトル |
|
|
タイトル |
Application of Collagen Scaffolds for Hepatic Stem-Like Cell Transplantation |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Somatic stem cell |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Collagen |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Scaffold |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cell transplantation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
UENO, Yasuharu
TERADA, Kunihiko
NAGAI, Hirokazu
WATANABE, Go
[ほか]
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Tissue engineering using somatic stem cells is a new and exciting technique which has the potential to facilitate tissue reconstruction. Recent studies on tissue engineering have indicated advantages in using collagen matrices to restitute the structure of an organ. Here we have demonstrated the efficacy of transplantation of hepatic stem-like (HSL) cells, a previously established liver epithelial cell line with potential for differentiation, using type I collagen sponge. To this end, HSL cells were cultured and transplanted into Nagase's analbuminemic rat with spongy type I collagen matrices. Consequently, HSL was able to express both albumin and TAT after the culture in collagen sponge. In addition, the levels of serum albumin in recipient rats were found to increase up to 1.5 fold relative to controls after transplantation. These findings suggest that HSL cells are able to differentiate into functional hepatocytes, and that biodegradable collagen sponge may enhance hepatic differentiation of HSL cells by providing an appropriate microenvironment. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
秋田医学
巻 31,
号 2,
p. 113-119,
発行日 2004-09-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
akigaku31-2c.pdf (438.5 kB)
