| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-01-18 |
| タイトル |
|
|
タイトル |
Immunohistochemical and Morphological Changes in Chipmunk Carotid Body during Hibernaiton |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
TH |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
neuroactive substance |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hibernation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
carotid body |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
chipmunk |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
FUKUHARA, Kohko
YOSHIZAKI, Katsuaki
WU, Yi
SENOO, Haruki
OHTOMO, Kazuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Mammalian hibernators experience drastic changes in vital signs such as body temperature, respiratory rate, and heart rate during hibernation because of periodic arousals during which vital signs return to non-hibernating levels. The carotid body, an arterial chemoreceptor organ regulating respiration, contains several neuroactive substances. However, little is known about changes of neuroactive substances in the carotid body during hibernation. Immunohistochemical study using antibodies against neuroactive substances, namely tyrosine hydroxylase (TH), methionine-enkephalin (MetEnk) , and gamma-aminobutyric acid (GABA) showed that immunoreactivities for TH, Met-Enk and GABA in type I cells of carotid bodies in hibernating animals increased in comparison with those in non-hibernating ones. Furthermore, we monitored vital signs of chipmunks during arousal from hibernation, and found that the heart rate increased exponentially and the respiratory rate increased linearly as body temperature gradually increased. Subsequent examination of TH-immunoreactivity in carotid bodies during arousal showed that the TH-immunoreactivity decreased during the course of arousal from hibernation. The type I cells enlarged in size during hibernation, but the sinusoidal capillaries around them did not. These results suggest that several neuroactive substances in type I cells playa significant role in the regulation of chemoreception during the hibernating physiological state. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
秋田医学
巻 31,
号 1,
p. 71-81,
発行日 2004-05-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
akigaku31-1g.pdf (693.0 kB)
