| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-03-07 |
| タイトル |
|
|
タイトル |
Construction of Sphingolipids Libraries and their Utilities |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sphingosine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
phyiosphingosine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
carba-D-aldohexopyranose |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ceramide library |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Park, Jeong-Ju
Yu, Seok-Ho
Chung, Sung-Kee
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Sphingolipids such as ceramide and glycosylceramide have recently attracted intense research interests because of their roles as signalling molecules in many important physiological processes, such as apoptosis, inflammation and immune responses. Their well-defined modular structures are ideally amenable to library formation for medicinal chemistry investigations. We have developed practical, divergent synthetic routes to sphingosine and phytosphingosine isomers as well as to carba-sugar analogues of all D-aldohexopyranose isomers toward these goals. And then we have proceeded to prepare ceramide libraries, composed of more than 500 compounds each, based on these sphingosine and phytosphingosine isomers, and demonstrated their utility in cell-based bioassays involving activation of NF-кB and induction of apoptosis. We are also in the process of forming libraries of mono-glycosylceramide and mono-carba-glycosylceramide. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : International Journal of the Society of Materials Engineering for Resources
巻 14,
号 1/2,
p. 18-21,
発行日 2006-11-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1347-9725 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1095475X |
| 出版者 |
|
|
出版者 |
The Society of Materilas Engineering for resources of Japan |
|
言語 |
en |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.5188/ijsmer.14.18 |
ijsmer14d.pdf (601.0 kB)
