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  1. 20 医学系研究科・医学部
  2. 20A 学術誌論文
  3. 20A1 雑誌掲載論文

Neoadjuvant Chemoradiotherapy Followed by Esophagectomy with Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma Patients with Clinical Stage III and with Supraclavicular Lymph Node Metastasis

http://hdl.handle.net/10295/00006232
http://hdl.handle.net/10295/00006232
ac240e7d-379c-4cfe-abae-8890722b029a
名前 / ファイル ライセンス アクション
iA_2022_89.pdf iA_2022_89.pdf (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-02-23
タイトル
タイトル Neoadjuvant Chemoradiotherapy Followed by Esophagectomy with Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma Patients with Clinical Stage III and with Supraclavicular Lymph Node Metastasis
言語 en
言語
言語 eng
主題
主題Scheme Other
主題 esophageal cancer
主題
主題Scheme Other
主題 esophageal squamous cell carcinoma
主題
主題Scheme Other
主題 prognosis
主題
主題Scheme Other
主題 neoadjuvant treatment
主題
主題Scheme Other
主題 chemoradiotherapy
主題
主題Scheme Other
主題 NACRT
主題
主題Scheme Other
主題 three-field
主題
主題Scheme Other
主題 supraclavicular LN metastasis
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 Sato, Yusuke

× Sato, Yusuke

en Sato, Yusuke

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Motoyama, Satoru

× Motoyama, Satoru

en Motoyama, Satoru

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Wada, Yuki

× Wada, Yuki

en Wada, Yuki

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Wakita, Akiyuki

× Wakita, Akiyuki

en Wakita, Akiyuki

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Kawakita, Yuta

× Kawakita, Yuta

en Kawakita, Yuta

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Nagaki, Yushi

× Nagaki, Yushi

en Nagaki, Yushi

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Terata, Kaori

× Terata, Kaori

en Terata, Kaori

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Imai, Kazuhiro

× Imai, Kazuhiro

en Imai, Kazuhiro

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Anbai, Akira

× Anbai, Akira

en Anbai, Akira

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Hashimoto, Manabu

× Hashimoto, Manabu

en Hashimoto, Manabu

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Minamiya, Yoshihiro

× Minamiya, Yoshihiro

en Minamiya, Yoshihiro

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内容記述
内容記述タイプ Abstract
内容記述 Simple Summary This study aimed to clarify the efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy with three-field lymph node (LN) dissection for clinical Stage III patients and for clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. We observed that NACRT followed by esophagectomy with three-field lymph node dissection is feasible and offers the potential for long-term survival of these patients. It is also suggested that supraclavicular LNs should be treated as regional LNs at least in patients with upper and middle thoracic esophageal squamous cell carcinoma (ESCC). Background: Neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy is now the standard treatment for patients with resectable advanced thoracic esophageal squamous cell carcinoma (ESCC) worldwide. However, the efficacy of NACRT followed by esophagectomy with three-field lymph node dissection for clinical Stage III patients and for clinical Stage IVB patients with supraclavicular LN metastasis has not yet been determined. Methods: Between 2008 and 2018, 94 ESCC patients diagnosed as clinical Stage III and 18 patients diagnosed as clinical Stage IVB with supraclavicular LN metastasis as the only distant metastatic factor were treated with NACRT followed by esophagectomy with extended lymph node dissection at Akita University Hospital. Long-term survival and the patterns of recurrence in these 112 patients were analyzed. Results: The median follow-up period of censored cases was 60 months. The five-year OS and DSS rates among the clinical Stage III patients were 57.6% and 66.6%, respectively. The five-year OS and DSS rates among the clinical Stage IVB patients were 41.3% and 51.6%, respectively. The most frequent recurrence pattern was distant metastasis (69.2%) in the Stage III patients and LN metastasis (75.0%) in the Stage IVB patients. Conclusion: NACRT followed by esophagectomy with three-field LN dissection is feasible and offers the potential for long-term survival of clinical Stage III ESCC patients and even clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. At least in patients with upper and middle thoracic ESCC, treating supraclavicular LNs as regional LNs seems to be appropriate.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : CANCERS

巻 13, 号 5, 発行日 2021
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2072-6694
出版者
出版者 MDPI
言語 en
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/cancers13050983
権利情報
権利情報 © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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