{"_buckets": {"deposit": "579b66c9-3822-4130-89f1-d618103510b6"}, "_deposit": {"created_by": 3, "id": "5920", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5920"}, "status": "published"}, "_oai": {"id": "oai:air.repo.nii.ac.jp:00005920", "sets": ["940"]}, "author_link": ["17299", "17306", "17304", "17307", "17305", "17301", "17297", "17302", "17303", "17300", "17298"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "CANCERS"}]}]}, "item_10001_description_5": {"attribute_name": "内容記述（抄録）", "attribute_value_mlt": [{"subitem_description": "Simple Summary This study aimed to clarify the efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy with three-field lymph node (LN) dissection for clinical Stage III patients and for clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. We observed that NACRT followed by esophagectomy with three-field lymph node dissection is feasible and offers the potential for long-term survival of these patients. It is also suggested that supraclavicular LNs should be treated as regional LNs at least in patients with upper and middle thoracic esophageal squamous cell carcinoma (ESCC). Background: Neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy is now the standard treatment for patients with resectable advanced thoracic esophageal squamous cell carcinoma (ESCC) worldwide. However, the efficacy of NACRT followed by esophagectomy with three-field lymph node dissection for clinical Stage III patients and for clinical Stage IVB patients with supraclavicular LN metastasis has not yet been determined. Methods: Between 2008 and 2018, 94 ESCC patients diagnosed as clinical Stage III and 18 patients diagnosed as clinical Stage IVB with supraclavicular LN metastasis as the only distant metastatic factor were treated with NACRT followed by esophagectomy with extended lymph node dissection at Akita University Hospital. Long-term survival and the patterns of recurrence in these 112 patients were analyzed. Results: The median follow-up period of censored cases was 60 months. The five-year OS and DSS rates among the clinical Stage III patients were 57.6% and 66.6%, respectively. The five-year OS and DSS rates among the clinical Stage IVB patients were 41.3% and 51.6%, respectively. The most frequent recurrence pattern was distant metastasis (69.2%) in the Stage III patients and LN metastasis (75.0%) in the Stage IVB patients. Conclusion: NACRT followed by esophagectomy with three-field LN dissection is feasible and offers the potential for long-term survival of clinical Stage III ESCC patients and even clinical Stage IVB patients with supraclavicular LN metastasis as the only distant metastatic factor. At least in patients with upper and middle thoracic ESCC, treating supraclavicular LNs as regional LNs seems to be appropriate.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/cancers13050983", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_25": {"attribute_name": "関連リンク", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://dx.doi.org/10.3390/cancers13050983"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.3390/cancers13050983", "subitem_relation_type_select": "DOI"}}]}, "item_10001_rights_15": {"attribute_name": "著作権等", "attribute_value_mlt": [{"subitem_rights": "© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access\narticle distributed under the terms and conditions of the Creative Commons Attribution\n(CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2072-6694", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sato, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "17297", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motoyama, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "17298", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wada, Yuki"}], "nameIdentifiers": [{"nameIdentifier": "17299", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakita, Akiyuki"}], "nameIdentifiers": [{"nameIdentifier": "17300", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakita, Yuta"}], "nameIdentifiers": [{"nameIdentifier": "17301", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagaki, Yushi"}], "nameIdentifiers": [{"nameIdentifier": "17302", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Terata, Kaori"}], "nameIdentifiers": [{"nameIdentifier": "17303", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "17304", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Anbai, Akira"}], "nameIdentifiers": [{"nameIdentifier": "17305", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "17306", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamiya, Yoshihiro"}], "nameIdentifiers": [{"nameIdentifier": "17307", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-02-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "iA_2022_89.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "iA_2022_89.pdf", "url": "https://air.repo.nii.ac.jp/record/5920/files/iA_2022_89.pdf"}, "version_id": "4c99de86-7f58-45b0-8d8c-187407fee8b4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "esophageal cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": " esophageal squamous cell carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": " prognosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": " neoadjuvant treatment", "subitem_subject_scheme": "Other"}, {"subitem_subject": " chemoradiotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": " NACRT", "subitem_subject_scheme": "Other"}, {"subitem_subject": " three-field", "subitem_subject_scheme": "Other"}, {"subitem_subject": " supraclavicular LN metastasis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Neoadjuvant Chemoradiotherapy Followed by Esophagectomy with Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma Patients with Clinical Stage III and with Supraclavicular Lymph Node Metastasis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Neoadjuvant Chemoradiotherapy Followed by Esophagectomy with Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma Patients with Clinical Stage III and with Supraclavicular Lymph Node Metastasis"}]}, "item_type_id": "10001", "owner": "3", "path": ["940"], "permalink_uri": "http://hdl.handle.net/10295/00006232", "pubdate": {"attribute_name": "公開日", "attribute_value": "2023-02-23"}, "publish_date": "2023-02-23", "publish_status": "0", "recid": "5920", "relation": {}, "relation_version_is_last": true, "title": ["Neoadjuvant Chemoradiotherapy Followed by Esophagectomy with Three-Field Lymph Node Dissection for Thoracic Esophageal Squamous Cell Carcinoma Patients with Clinical Stage III and with Supraclavicular Lymph Node Metastasis"], "weko_shared_id": -1}