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  1. 20 医学系研究科・医学部
  2. 20A 学術誌論文
  3. 20A1 雑誌掲載論文

Reg3 alpha and Reg3 beta Expressions Followed by JAK2/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model

http://hdl.handle.net/10295/00006209
http://hdl.handle.net/10295/00006209
64e75786-8ce7-49b9-b7c5-66abc27f979a
名前 / ファイル ライセンス アクション
iA_2022_66.pdf iA_2022_66.pdf (6.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-02-23
タイトル
タイトル Reg3 alpha and Reg3 beta Expressions Followed by JAK2/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model
言語 en
言語
言語 eng
主題
主題Scheme Other
主題 ALPPS
主題
主題Scheme Other
主題 Reg3 alpha
主題
主題Scheme Other
主題 Reg3 beta
主題
主題Scheme Other
主題 JAK2
主題
主題Scheme Other
主題 STAT3 pathway
主題
主題Scheme Other
主題 liver hypertrophy
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 Otsuka, Naohiko

× Otsuka, Naohiko

en Otsuka, Naohiko

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Yoshioka, Masato

× Yoshioka, Masato

en Yoshioka, Masato

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Abe, Yuki

× Abe, Yuki

en Abe, Yuki

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Nakagawa, Yasuhiko

× Nakagawa, Yasuhiko

en Nakagawa, Yasuhiko

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Uchinami, Hiroshi

× Uchinami, Hiroshi

en Uchinami, Hiroshi

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Yamamoto, Yuzo

× Yamamoto, Yuzo

en Yamamoto, Yuzo

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内容記述
内容記述タイプ Abstract
内容記述 To explore the underlying mechanism of rapid liver hypertrophy by liver partition in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), liver partition at different sites was investigated. Increased inflammatory cytokines owing to the liver partition have been reportedly responsible. If this were true, rapid liver hypertrophy should be achieved regardless of where the liver was split. A male Sprague-Dawley rat model was created, in which a liver split was placed inside the portal vein ligated lobe (PiLL), in addition to the ALPPS and portal vein ligation (PVL) models. Liver regeneration rate, inflammatory cytokine levels, activation status of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and expressions of regenerating islet-derived (Reg)3 alpha and Reg3 beta were investigated. The liver regeneration rate was significantly higher in the ALPPS group than in the PiLL group, whereas inflammatory cytokine levels were nearly equal. Additional volume increase in ALPPS group over PVL and PiLL groups was JAK2/STAT3-dependent. Reg3 alpha and Reg3 beta expressions were observed only in the ALPPS group. An increase in inflammatory cytokines was not enough to describe the mechanism of rapid liver hypertrophy in ALPPS. Expressions of Reg3 alpha and Reg3 beta could play an important role in conjunction with an activation of the JAK2/STAT3 pathway.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

巻 21, 号 11, 発行日 2020
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1422-0067
出版者
出版者 MDPI
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/ijms21114077
権利情報
権利情報 © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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