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Reg3 alpha and Reg3 beta Expressions Followed by JAK2/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model
http://hdl.handle.net/10295/00006209
http://hdl.handle.net/10295/0000620964e75786-8ce7-49b9-b7c5-66abc27f979a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
iA_2022_66.pdf (6.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-02-23 | |||||
| タイトル | ||||||
| タイトル | Reg3 alpha and Reg3 beta Expressions Followed by JAK2/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | ALPPS | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Reg3 alpha | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | Reg3 beta | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | JAK2 | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | STAT3 pathway | |||||
| 主題 | ||||||
| 主題Scheme | Other | |||||
| 主題 | liver hypertrophy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 作成者 |
Otsuka, Naohiko
× Otsuka, Naohiko× Yoshioka, Masato× Abe, Yuki× Nakagawa, Yasuhiko× Uchinami, Hiroshi× Yamamoto, Yuzo |
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| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To explore the underlying mechanism of rapid liver hypertrophy by liver partition in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), liver partition at different sites was investigated. Increased inflammatory cytokines owing to the liver partition have been reportedly responsible. If this were true, rapid liver hypertrophy should be achieved regardless of where the liver was split. A male Sprague-Dawley rat model was created, in which a liver split was placed inside the portal vein ligated lobe (PiLL), in addition to the ALPPS and portal vein ligation (PVL) models. Liver regeneration rate, inflammatory cytokine levels, activation status of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and expressions of regenerating islet-derived (Reg)3 alpha and Reg3 beta were investigated. The liver regeneration rate was significantly higher in the ALPPS group than in the PiLL group, whereas inflammatory cytokine levels were nearly equal. Additional volume increase in ALPPS group over PVL and PiLL groups was JAK2/STAT3-dependent. Reg3 alpha and Reg3 beta expressions were observed only in the ALPPS group. An increase in inflammatory cytokines was not enough to describe the mechanism of rapid liver hypertrophy in ALPPS. Expressions of Reg3 alpha and Reg3 beta could play an important role in conjunction with an activation of the JAK2/STAT3 pathway. | |||||
| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 書誌情報 |
en : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 21, 号 11, 発行日 2020 |
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| 収録物識別子 | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1422-0067 | |||||
| 出版者 | ||||||
| 出版者 | MDPI | |||||
| 関連情報 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3390/ijms21114077 | |||||
| 権利情報 | ||||||
| 権利情報 | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
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