| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-02-19 |
| タイトル |
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|
タイトル |
Digital quantitative analysis of mast cell infiltration in interstitial cystitis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cystitis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
detrusor |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
diagnosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
differential |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
interstitial |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
mast cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
mastocytosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
urinary bladder |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Akiyama, Yoshiyuki
Maeda, Daichi
Morikawa, Teppei
Niimi, Aya
Nomiya, Akira
Yamada, Yukio
Igawa, Yasuhiko
Goto, Akiteru
Fukayama, Masashi
Homma, Yukio
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
AimsTo evaluate the significance of mast cell infiltration in interstitial cystitis (IC) by comparison with equally inflamed controls using a digital quantification technique. MethodsBladder biopsy specimens from 31 patients with Hunner type IC and 38 patients with non-Hunner type IC were analyzed. Bladder biopsy specimens from 37 patients without IC, including 19 non-specific chronic cystitis (non-IC cystitis) specimens and 18 non-inflamed bladder (normal bladder) specimens, were used as controls. Mast cell tryptase-, CD3-, CD20-, and CD138-immunoreactive cells were quantified using digital image analysis software to evaluate both mast cell and lymphoplasmacytic cell densities. Mast cell and lymphoplasmacytic cell densities were counted independently in the entire lamina propria and detrusor areas and compared among the four groups. ResultsIn the lamina propria, there were no significant differences in mast cell and lymphoplasmacytic cell densities between Hunner type IC and non-IC cystitis or between non-Hunner type IC and normal bladder specimens. In the detrusor, the mast cell densities were not significantly different among the four groups. Mast cell density was correlated with lymphoplasmacytic cell density, but not with clinical parameters. ConclusionsMast cell density is not significantly different between IC specimens and non-IC control specimens with a similar degree of background inflammation. The intensity of mast cell infiltration generally correlated with that of lymphoplasmacytic cells. We conclude that mast cell count is of no value in the differential diagnosis between IC and other etiologies. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Neurourology and Urodynamics
巻 37,
号 2,
p. 650-657,
発行日 2018
|
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0733-2467 |
| 出版者 |
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|
出版者 |
John Wiley and Sons Inc |
| 関連情報 |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1002/nau.23365 |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2017 The Authors. Neurourology and Urodynamics Published by Wiley Periodicals, Inc. |
iA_2022_47.pdf (1.2 MB)
