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  1. 30 理工学研究科・理工学部(含:旧鉱山・工学資源学部)
  2. 30A 学術誌論文
  3. 30A1 雑誌掲載論文

Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy

http://hdl.handle.net/10295/00006162
http://hdl.handle.net/10295/00006162
76d80685-9ffd-4506-adb3-7328e426db4b
名前 / ファイル ライセンス アクション
riA_2022_5.pdf riA_2022_5.pdf (699.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2023-02-18
タイトル
タイトル Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy
言語 en
言語
言語 eng
主題
主題Scheme Other
主題 Bucillamine
主題
主題Scheme Other
主題 Comparative proteomic analysis
主題
主題Scheme Other
主題 Glomerular proteins
主題
主題Scheme Other
主題 Laser microdissection
主題
主題Scheme Other
主題 Mass spectrometry
主題
主題Scheme Other
主題 Membranous nephropathy
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
作成者 Kaga, Hajime

× Kaga, Hajime

en Kaga, Hajime

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Matsumura, Hirotoshi

× Matsumura, Hirotoshi

en Matsumura, Hirotoshi

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Suzuki, Takehiro

× Suzuki, Takehiro

en Suzuki, Takehiro

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Dohmae, Naoshi

× Dohmae, Naoshi

en Dohmae, Naoshi

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Odaka, Masafumi

× Odaka, Masafumi

en Odaka, Masafumi

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Komatsuda, Atsushi

× Komatsuda, Atsushi

en Komatsuda, Atsushi

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Takahashi, Naoto

× Takahashi, Naoto

en Takahashi, Naoto

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Wakui, Hideki

× Wakui, Hideki

en Wakui, Hideki

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内容記述
内容記述タイプ Abstract
内容記述 Background
Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed in Japan, was reported to cause a rare form of secondary MN (sMN). Between these MN forms, comparative proteomic analysis of glomerular proteins has not been performed.
Methods
We used renal biopsy specimens from 6 patients with PLA2R Ab (+) pMN, 6 patients with PLA2R Ab (‒) pMN, 6 patients with BCL-induced sMN, and 5 control cases (time 0 transplant biopsies). Proteins were extracted from laser-microdissected glomeruli and analyzed using mass spectrometry. The quantification values of protein abundance in each MN group were compared with those in the control group.
Results
More than 800 proteins with high confidence were identified. Principal component analysis revealed a different distribution between the pMN and sMN groups. For further analysis, 441 proteins matched with ≥ 3 peptides were selected. Among the pMN and sMN groups, we compared the profiles of several protein groups based on the structural and functional characteristics, such as immunoglobulins, complements, complement-regulating proteins, podocyte-associated proteins, glomerular basement membrane proteins, and several proteins that are known to be associated with kidney diseases, including MN. In all MN groups, increased levels of immunoglobulins (IgG, IgA, and IgM), complements (C3, C4, and C9), complement factor H-related protein 5, type XVIII collagen, calmodulin, polyubiquitin, and ubiquitin ligase were observed. For some proteins, such as type VII collagen and nestin, the fold-change values were significantly different between the pMN and sMN groups.
Conclusions
Between the pMN and BCL-induced sMN groups, we observed common and different alterations in protein levels such as known disease-associated proteins and potential disease marker proteins.
言語 en
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
書誌情報 en : Clinical Proteomics

巻 19, 号 1, 発行日 2022
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 15426416
出版者
出版者 BioMed Central Ltd
関連情報
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1186/s12014-022-09365-x
権利情報
権利情報 © The Author(s) 2022.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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