| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-10-24 |
| タイトル |
|
|
タイトル |
Focal brain lactate accumulation in metformin-induced encephalopathy without systemic lactic acidosis: A case report suggesting mitochondrial vulnerability in lentiform fork sign |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Metformin-induced encephalopathy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lentiform fork sign |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chronic kidney disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lactate |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Diabetes |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mitochondrial respiratory complex I |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Hanazono, Akira
Takahashi, Yoshiko
Sanpei, Yui
Kamada, Sachiko
Sugawara, Masashiro
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Metformin causes metabolic encephalopathy in some patients with end-stage chronic kidney disease, resulting in impaired consciousness and parkinsonism. This encephalopathy has a very characteristic magnetic resonance imaging feature in lentiform nuclei known as the “lentiform fork sign”. However, the mechanism is unknown. Here, we report a case of metformin-induced encephalopathy with a novel observation of lactate accumulation in the lentiform nuclei on magnetic resonance spectroscopy without systemic lactic acidosis. Since metformin is an inhibitor of mitochondrial complex-I, this focal brain lactate accumulation implies that a part of the pathogenesis of metformin-induced encephalopathy is the focal vulnerability of mitochondria to metformin in the lentiform nuclei. When metformin causes encephalopathy, not only testing for serum lactic acidosis and performing routine magnetic resonance imaging but also evaluation of brain lactate accumulation by magnetic resonance spectroscopy should be required to elucidate the etiology. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
eNeurologicalSci
巻 25,
発行日 2021
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24056502 |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.ensci.2021.100383 |
| 権利情報 |
|
|
権利情報 |
© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
iA_2022_6.pdf (787.8 kB)
