| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-02-08 |
| タイトル |
|
|
タイトル |
Long-term survival of a patient with diffuse midline glioma in the pineal region: A case report and literature review |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bevacizumab |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Diffuse midline glioma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
High-dose radiotherapy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Maximum resection |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Pineal tumors |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ono, Takahiro
Kuwashige, Haruka
Adachi, Jun-Ichi
Takahashi, Masataka
Oda, Masaya
Kumabe, Toshihiro
Shimizu, Hiroaki
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Diffuse midline glioma (DMG) is an invasive astrocytic tumor arisen from midline structures, such as the pons and thalamus. Five cases of DMG in the pineal region have been reported, but the clinical course was poor; there was no case of survival for more than 2 years.
Case Description: We report the case of a 12-year-old boy with DMG in the pineal region who is living a normal daily life for more than 6 years following multimodal treatment. He complained of a headache accompanied by vomiting that had gradually worsened 1 month previously, and initial magnetic resonance imaging revealed a pineal tumor. Germinoma was initially suspected; however, a combination of chemotherapy using carboplatin and etoposide was ineffective. The first surgery was performed through the left occipital transtentorial approach (OTA); the diagnosis was DMG. After 60 Gy radiotherapy concomitant with temozolomide (TMZ), the tumor enlarged. Second surgery was performed through bilateral OTAs, and 90% of the tumor was removed. In addition, stereotactic radiotherapy (30 Gy, six fractions) was administered, and the local equivalent dose in 2 Gy/fraction reached 97.5 Gy. Maintenance chemotherapy using TMZ and bevacizumab was continued for 2 years. After finishing chemotherapy, the enhancing lesion enlarged again, and bevacizumab monotherapy was effective. Now, at 6 years after diagnosis, the patient leads an ordinary life as a student.
Conclusion: Maximum resection and high-dose radiotherapy followed by bevacizumab may have been effective in the present case. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
Surgical Neurology International
巻 12,
号 612,
p. 1-6,
発行日 2021
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2152-7806 |
| 出版者 |
|
|
出版者 |
Scientific Scholar |
| 関連情報 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.25259/SNI_1141_2021 |
| 権利情報 |
|
|
権利情報 |
©2021 Surgical Neurology International This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
iA_2021_43 (2.1 MB)
