Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-11-11 |
タイトル |
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タイトル |
Trained innate lymphoid cells in allergic diseases |
言語 |
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言語 |
eng |
キーワード |
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主題Scheme |
Other |
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主題 |
Exhausted-like ILC2 |
キーワード |
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主題Scheme |
Other |
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主題 |
IL-10-producing ILC2 |
キーワード |
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主題Scheme |
Other |
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主題 |
Memory-like ILC2 |
キーワード |
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主題Scheme |
Other |
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主題 |
Trained ILC2 |
キーワード |
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主題Scheme |
Other |
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主題 |
Trained immunity |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Ebihara, Takashi
Tatematsu, Megumi
Fuchimukai, Akane
Yamada, Toshiki
Yamagata, Kenki
Takasuga, Shunsuke
Yamada, Takechiyo
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内容記述(抄録) |
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内容記述タイプ |
Other |
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内容記述 |
Group 2 innate lymphoid cells (ILC2s) reside in peripheral tissues such as the lungs, skin, nasal cavity, and gut and provoke innate type 2 immunity against allergen exposure, parasitic worm infection, and respiratory virus infection by producing TH2 cytokines. Recent advances in understanding ILC2 biology revealed that ILC2s can be trained by IL-33 or allergic inflammation, are long-lived, and mount memorylike type 2 immune responses to any other allergens afterwards. In contrast, IL-33, together with retinoic acid, induces IL-10-producing immunosuppressive ILC2s. In this review, we discuss how the allergic cytokine milieu and other immune cells direct the generation of trained ILC2s with immunostimulatory or immunosuppressive recall capability in allergic diseases and infections associated with type 2 immunity. The molecular mechanisms of trained immunity by ILCs and the physiological relevance of trained ILC2s are also discussed. |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.alit.2020.11.007 |
書誌情報 |
Allergology International
巻 70,
号 2,
p. 174-180,
発行日 2021
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ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13238930 |
NCID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11615545 |
出版者 |
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出版者 |
Elsevier B.V. |
関連リンク |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.alit.2020.11.007 |
著作権等 |
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権利情報 |
Copyright © 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access |