| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-06-04 |
| タイトル |
|
|
タイトル |
Risk factors for low adherence to methylphenidate treatment in pediatric patients with attention-deficit/hyperactivity disorder |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ishizuya, Asami
Enomoto, Minori
Tachimori, Hisateru
Takahashi, Hidehiko
Sugihara, Genichi
Kitamura, Shingo
Mishima, Kazuo
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| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Poor adherence is a major concern in the treatment of attention-deficit/hyperactivity disorder (ADHD). The objective of this study was to evaluate factors linked to early interruption of and low adherence to treatment with osmotic-release oral system methylphenidate hydrochloride (OROS-MPH) in pediatric patients with ADHD. A total of 1353 young people (age 6–17 years) with a diagnosis of ADHD who newly started OROS-MPH were extracted from the pharmacoepidemiological data of 3 million people in Japan. The cohort was retrospectively surveyed every month for 12 months. Ten possible risk factors were extracted from the data and analyzed by multivariable logistic regression. Sensitivity analysis was conducted to ensure the robustness of the analysis. The results revealed that treatment adherence was generally poor, with a tendency for discontinuation in the early stage. Multivariable logistic regression results showed that adherence is reduced by female sex, lower starting dose, and concomitant atomoxetine or hypnotics. These findings may help clinicians to predict the risk of poor adherence in the early stage of treatment and improve not only patients’ symptoms, but also their quality of life. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : scientific reports
巻 11,
号 1707(2021),
発行日 2021-01-18
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| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2045-2322 |
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 関連情報 |
|
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1038/s41598-021-81416-z |
iA_2021_8 (1.1 MB)
