| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-07-05 |
| タイトル |
|
|
タイトル |
INCREASED EXPRESSION OF TOLL-LIKE RECEPTOR 4 IN HEPATOCELLULAR CARCINOMA ─ ITS CLINICOPATHOLOGICAL SIGNIFICANCE ─ |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
toll-like receptor 4 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lipopolysaccharide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatocellular carcinoma |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
surgical specimen |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00003591 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ito , Satoru
YAMAMOTO, Yohei
NISHIJIMA, Aki
HIROSHIMA, Yuko
ENOMOTO, Katsuhiko
Omori, Yasufumi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Lipopolysaccharide (LPS), known as endotoxin, is produced by Gram-negative bacteria and transported from the intestine to the liver via the portal vein. While LPS is cytotoxic and gives damages to hepatocytes, it also functions as an exogenous ligand for toll-like receptor 4 (TLR4) expressed in the plasma membrane. Stimulated by LPS, TLR4 activates MyD88-NF-κB signaling pathway in hepatocytes, leading to tissue repair and cell proliferation. It has thus been postulated that a combination of LPS-induced hepatic injury and TLR4-mediated tissue repair may lead to development of hepatocellular carcinoma (HCC). As recently reported, the increased expression of TLR4 in HCC is related to poor prognosis, suggesting involvement of TLR4 in HCC progression after its development. To explore correlation of clinicopathological characteristics of HCC with TLR4 expression, we immunostained TLR4 protein in both HCC and its neighboring non-cancerous area by using 99 resected livers bearing HCC. In general, TLR4 expression was significantly higher in HCC areas than in non-cancerous areas. When correlation of the increased expression of TLR4 with different clinicopathological factors was assessed, tumor size and expanding growth pattern were significantly correlated with the TLR4 expression level, suggesting that TLR4 is closely related to cell proliferation but not invasive phenotype. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 44,
号 3/4,
p. 131-137,
発行日 2018-03
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai44_3_4(131) (948.8 kB)
