| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2018-07-05 |
| タイトル |
|
|
タイトル |
EFFECTS OF ALENDRONATE ON BONE MINERAL DENSITY AND NOCICEPTIVE PAIN IN CHRONIC PAIN MODEL RATS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
alendronate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
bone mineral density |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
chronic pain model |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.20569/00003590 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Suzuki, Masazumi
MIYAKOSHI, Naohisa
KASUKAWA, Yuji
Tsuchie, Hiroyuki
Fujii, Masashi
Sato, Chie
Masutani, Norimitu
Kawano, Tetuya
Akagawa, Manabu
Ono, Yuichi
Yuasa, Yusuke
Nagahata, Itsuki
Shimada, Yoichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective : Alendronate (ALN) is used to treat postmenopausal osteoporosis, and it is also considered to have analgesic effect. However, the effects of ALN on hyperalgesia in the postmenopausal osteoporosis and chronic pain model are still unclear. In this study, the effects of ALN on nociceptive pain, as well as bone mineral density (BMD), were evaluated by a chronic constriction injury (CCI) model in ovariectomized (OVX) rats. Methods : Four-week-old, Wistar rats underwent OVX, and then the left sciatic nerve was ligated to make a CCI, at 8 weeks of age. ALN (0.15 mg/kg/week) or its vehicle was administered for 2 weeks starting on the 0th day of CCI. Behavioral evaluations with the von Frey test and the hot plate test were performed on days 0 (8 weeks old) and 14 (10 weeks old). After evaluation, bilateral femora were harvested for BMD measurement. Results : Two weeks of treatment with ALN showed no significant improvement of mechanical and thermal hypersensitivity in CCI limbs. ALN treatment significantly increased femoral BMD in the sham and CCI limbs compared with vehicle treatment (p < 0.01) at 10 weeks old. Conclusion : Two weeks of treatment with ALN improved BMD in CCI limbs in OVX rats, but mechanical and thermal hypersensitivity were not improved by ALN treatment. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
en : Akita journal of medicine
巻 44,
号 3/4,
p. 125-130,
発行日 2018-03
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| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0386-6106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai44_3_4(125) (597.6 kB)
