| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2014-06-24 |
| タイトル |
|
|
タイトル |
Involvement of Nitric Oxide In Simulated Retinal Ischemia |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Retina |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
simulated ischemia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
glutamate receptor antagonist |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
nitric oxide synthetase inhibitors |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
nitric oxide donor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 別タイトル |
|
|
その他のタイトル |
疑似虚血を誘導した網膜における一酸化窒素の役割の解明 |
| 作成者 |
神, 大介
Jin, Daisuke
|
| 内容記述（抄録） |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Purpose. To examine the involvement of nitric oxide (NO) in the development of ischemic retinal degeneration using glutamate receptor antagonists, inhibitors of nitric oxide syntheses (NOS), and NO donors. Methods. Simulated ischemia was induced in the rat ex vivo retinal preparations by deprivation of oxygen and glucose from the incubation medium. The NMDA receptor antagonist (MK-801) and non-NMDA receptor antagonist (GYKI) were applied to the ischemic retinal preparations in combination with different types of NOS inhibitors. The neuroprotective effects of these agents were evaluated by morphologically and biochemically. In addition, the deteriorating actions of NO donors to the control and ischemic retina were also examined. Results. Simulated ischemia produced severe acute neurodegeneration. This neurodegeneration was prevented by the combination of GYKI and MK-801. However, the NO donor induced severe retinal degeneration under the simulated ischemia, in spite of the co-administration of GYKI and MK-801. A neuronal NOS inhibitor offered substantial protection against neuronal damage combined with GYKI. Administration of NO donors invalidated the neuroprotective effects of MK-801and GYKI against the simulated ischemia. Conclusions. The present study revealed that the NO release after activation of glutamate receptors seems to play an important role in the neuronal cell death induced by ischemia. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
発行日 2014-06-01
|
| 関連リンク |
|
|
|
識別子タイプ |
HDL |
|
|
関連識別子 |
http://hdl.handle.net/10295/2503 |
|
|
関連名称 |
http://hdl.handle.net/10295/2503 |
| 備考 |
|
|
|
秋田大学審査学位論文（秋田医学,40(3/4),p135-p142掲載論文の著者最終稿） |
| 学位名 |
|
|
学位名 |
博士（医学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
11401 |
|
|
学位授与機関名 |
秋田大学 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2014-03-27 |
| 学位授与番号 |
|
|
学位授与番号 |
乙第630号 |
本文 (1.1 MB)
