| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-06-16 |
| タイトル |
|
|
タイトル |
Involvement of Nitric Oxide in Simulated Retinal Ischemia |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Retina |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
simulated ischemia |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
glutamate receptor antagonist |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nitric oxide synthetase inhibitors |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
nitric oxide donor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Jin, Daisuke
Ishikawa, Makoto
Yoshitomi, Takeshi
Izumi, Yukitoshi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose. To examine the involvement of nitric oxide (NO) in the development of ischemic retinal degeneration using glutamate receptor antagonists, inhibitors of nitric oxide synthetase (NOS), and NO donors. Methods. Simulated ischemia was induced in the rat ex vivo retinal preparations by deprivation of oxygen and glucose from the incubation medium. The NMDA receptor antagonist (MK-801) and non-NMDA receptor antagonist (GYKI) were applied to the ischemic retinal preparations in combination with different types of NOS inhibitors. The neuroprotective effects of these agents were evaluated by morphologically and biochemically. In addition, the deteriorating actions of NO donors to the control and ischemic retina were also examined. Results. Simulated ischemia produced severe acute neurodegeneration. This neurodegeneration was prevented by the combination of GYKI and MK-801. However, the NO donor induced severe retinal degeneration under the simulated ischemia, in spite of the co-administration of GYKI and MK-801. A neuronal NOS inhibitor offered substantial protection against neuronal damage combined with GYKI. Administration of NO donors invalidated the neuroprotective effects of MK-801and GYKI against the simulated ischemia. Conclusions. The present study revealed that the NO release after activation of glutamate receptors seems to play an important role in the neuronal cell death induced by ischemia. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 40,
号 3/4,
p. 135-141,
発行日 2014-03-31
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai40-3_4(135).pdf (1.3 MB)
