| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-01-07 |
| タイトル |
|
|
タイトル |
SYMPATHETIC AND PARASYMPATHETIC CONTROL OF HEART RATE RESPONSE TO RESTRAINT STRESS DURING THE VULNERABLE PERIOD IN NEWBORN RATS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
newborn rats |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
heart rate |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
restraint stress |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
accentuated antagonism |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sudden infant death syndrome |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Tokunaga, Jun
Sato, Shinichi
Kanbayashi, Takashi
Imanishi, Aya
Sagawa, Yohei
Sato, Masatoshi
Sakai, Noriaki
Nishino, Seiji
Shimizu, Tetsuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Newborn infants and animals undergo dramatic development of the autonomic nervous system ; however, there remains a lack of normative information concerning the vulnerable period. This study investigated the maturation of the heart rate (HR) and the autonomic regulation of HR responses to restraint stress during the first 2 postnatal weeks in rats. Autonomic blockade with atropine, metoprolol, and dual atropine/metoprolol blockade (2 mg/kg) at postnatal day (P) 4 and P12 demonstrated predominantly sympathetic effects on baseline HR. From birth to P9, rats restrained by electrocardiography electrodes for 5 min displayed slow cardiodeceleration, which changed into transient bradycardia (TB) during P9-14. Interestingly, this TB was abolished by autonomic blockade on P12 ; stable tachycardia (18% increase) and unstable HR were observed under parasympathetic and sympathetic blockade, respectively. In addition, HR under dual blockade increased by 25% (p=0.009) after the animals were restrained but not under dual blockade with a 10-fold higher dose. These results suggest that TB is mediated by a complex sympathetic-parasympathetic interaction, which is immature during the vulnerable period and can potentially cause life-threatening cardiac events. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 40,
号 2,
p. 89-103,
発行日 2013-11-21
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai40-2(89).pdf (1.8 MB)
