| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-10-18 |
| タイトル |
|
|
タイトル |
Elevated High Morbility Group Box Protein 1 on Pathological Findings in Subclinical Interstitial Pneumonia During Early Phase of Thoracic Surgery |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lung injury |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
interstitial pneumonia |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
ARDS |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ono, Takashi
Saito, Hajime
Minamiya, Yoshihiro
Nanjo, Hiroshi
Takahasi, Naoko
Ito, Manabu
Motoyama, Satoru
Ogawa, Jun-ichi
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Some cases of post-surgical acute respiratory distress syndrome (ARDS) may be an acute exacerbation of idiopathic pulmonary fibrosis (IPF) including subclinical IP, and pathological interstitial pneumonia (IP) is a predictor of the ARDS high-risk group. Although one-lung-ventilation (OLV) has become established procedure during thoracic surgery, there is little data on the re-expansion of pulmonary edema after surgery. In the present study, we evaluated the possibility that occult lung injury occurs in pathological IP patients during the early phase of thoracic surgery. [Methods] Study was performed in 22 patients who underwent pulmonary resection at our institute. Plasma levels of interleukin (IL)6, IL8 and high mobility group box protein1 (HMGB1) were measured during the pre-, peri-and postoperative periods. [Results] Serum levels of IL-6 and IL-8 increased after surgery ; however, there were no significant differences between the IP and non-IP groups. Meanwhile, serum levels of HMGB1 were significantly higher at 30 min after OLV in IP group, and those in IP group were continuously higher during the peri-and postoperative periods. [Conclusions] This study suggests that elevation of HMGB1, which might influence occult lung injury, occurred during OLV in IP group, and that it already existed before lung re-expansion. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 37,
号 2,
p. 75-84,
発行日 2010-01-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
akitai37(75).pdf (974.3 kB)
