| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2010-02-09 |
| タイトル |
|
|
タイトル |
DORSAL ROOT REGENERATION INTO TRANSPLANTS OF DORSAL OR VENTRAL HALF OF EMBRYONIC SPINAL CORD |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Calcitonin gene-related peptide |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dorsal root regeneration |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Embryonic spinal cord tissue |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immunohistochemistry |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Intraspinal transplantation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 作成者 |
Ohta, Tohru
Itoh, Yasunobu
Tessler, Alan
Mizoi, Kazuo
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Adult cut dorsal root axons regenerate into the transplants of embryonic spinal cord (ESC) and form functional synapses within the transplants. It is unknown whether the growth is specific to transplants of dorsal half of ESC, a normal target of most dorsal root axons, or whether it is due to properties shared by transplants of ventral half of ESC. We used calcitonin gene-related peptide (CGRP) immunohistochemistry to label to the subpopulations of regenerated adult dorsal root axons, quantitative analysis to compare the extent of dorsal root regeneration, and also compare neuronal composition within both transplants. Adult Sprague-Dawley rats received intraspinal grafts of dorsal or ventral half ESC (E14), and the L4 or L5 dorsal root was cut and juxtaposed to the transplants. Three months later sagittal sections were prepared for CGRP immunohistochemistry and Nissl-Myelin stain. Dorsal root axons regenerated into both kinds of transplants, but growth into dorsal half of ESC was more robust than that into ventral half of ESC. Histograms of the perikaryal area showed that the transplants of dorsal half ESC consisted of small neurons predominantly, whereas transplants of ventral half ESC consisted neurons of variable sizes with abundant myelination. These results indicate that both kinds of ESC may help to rebuild damaged spinal reflex circuits after spinal cord injury. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 秋田医学
巻 36,
号 2,
p. 133-142,
発行日 2009-11-01
|
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866106 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00009294 |
| 出版者 |
|
|
出版者 |
秋田医学会 |
|
言語 |
ja |
p133-142.pdf (2.0 MB)
